Genetic Variants and Haplotypes of Tryptophan Hydroxylase 2 and Reelin Genes May Be Linked with Attention Deficit Hyperactivity Disorder in Egyptian Children
Genetic Variants and Haplotypes of Tryptophan Hydroxylase 2 and Reelin Genes May Be Linked with Attention Deficit Hyperactivity Disorder in Egyptian Children
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DOI：
10.1021/acschemneuro.0c00136
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发表时间：
2020-07-15
影响因子：
5
通讯作者：
Abd el Naby, Sameh Abdallah
中科院分区：
文献类型：
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作者：
El Fotoh, Wafaa Moustafa M. Abo;Bayomy, Noha Rabie;Abd el Naby, Sameh Abdallah
注意缺陷多动障碍（ADHD）有多种病因，可能是遗传的，具有生物学和社会心理的动机。色氨酸羟化酶2 （TPH2）和Reelin （RELN）基因可能在引发ADHD中起关键作用。本病例对照研究的目的是探讨TPH2和RELN基因的遗传变异与ADHD的联系。100名患有多动症的埃及儿童和105名年龄和性别匹配的对照组构成了研究样本。采用实时荧光定量PCR法对TPH2 （rs11179027; rs1843809）和RELN （rs736707; rs362691）基因多态性进行分型。在所有研究参与者中评估TPH2和RELN基因多态性的等位基因和基因型频率。TPH2 rs11179027 （OR = 1.75, 95% CI = 1.08 ~ 2.85, p = 0.022）、TPH2 rs1843809 （OR = 3.67, 95% CI = 1.82 ~ 7.43, p = 0.022）、TPH2 rs11179027 （OR = 1.75, 95% CI = 1.08 ~ 2.85, p = 0.022）、TPH2 rs1843809 （OR = 3.67, 95% CI = 1.82 ~ 7.43, p = 0.022）的等位基因频率
Attention-deficit hyperactivity disorder (ADHD) has been proposed to stem from multiple etiologies, perhaps genetic in nature with biological and psychosocial motivates. Tryptophan hydroxylase 2 (TPH2) and Reelin (RELN) genes may play a key role in triggering ADHD. The purpose of this case-controlled study was to explore the linkage of the genetic variants of TPH2 and RELN genes with ADHD. One hundred Egyptian children with ADHD and 105 age and sex matched controls constituted the study samples. Genotyping was performed for TPH2 (rs11179027; rs1843809) and RELN (rs736707; rs362691) gene polymorphisms using real time PCR assay. The alleles and genotype frequencies of TPH2 and RELN gene polymorphisms were assessed in all study participants. The frequencies of the alleles of TPH2 rs11179027 (OR = 1.75, 95% CI = 1.08-2.85, p = 0.022), TPH2 rs1843809 (OR = 3.67, 95% CI = 1.82-7.43, p =