Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex.
Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex.
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DOI：
10.1016/j.euroneuro.2015.07.018
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Cassaday HJ
中科院分区：
文献类型：
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作者：
Pezze MA;Marshall HJ;Fone KC;Cassaday HJ
先前的研究表明，多巴胺 D1 受体拮抗剂会损害新物体识别记忆，但多巴胺 D1 受体刺激的影响仍有待确定。本研究调查了选择性多巴胺 D1 受体激动剂 SKF81297 对雄性 Wistar 大鼠新物体识别任务中获取和检索的影响。在采样阶段前 15 分钟给予 SKF81297（0.4 和 0.8 mg/kg s.c.），会在 10 分钟或 24 小时后评估新物体识别能力。在采样阶段后 24 小时以及在选择阶段前 15 分钟进行测试时，相同的治疗也会降低新物体识别记忆。这些数据表明 D1 受体刺激调节物体识别记忆的编码和检索。在采样阶段前 10 分钟，将 SKF81297（0.025 或 0.05 μg/侧）微量输注到内侧前额叶皮层 (mPFC) 的前边缘亚区域，也会损害新物体识别记忆，表明 mPFC 是介导 D1 受体刺激对视觉识别记忆影响的一个重要部位。
Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D1 receptor agonist SKF81297 on acquisition and retrieval in the novel object recognition task in male Wistar rats. SKF81297 (0.4 and 0.8 mg/kg s.c.) given 15 min before the sampling phase impaired novel object recognition evaluated 10 min or 24 h later. The same treatments also reduced novel object recognition memory tested 24 h after the sampling phase and when given 15 min before the choice session. These data indicate that D1 receptor stimulation modulates both the encoding and retrieval of object recognition memory. Microinfusion of SKF81297 (0.025 or 0.05 μg/side) into the prelimbic sub-region of the medial prefrontal cortex (mPFC) in this case 10 min before the sampling phase also impaired novel object recognition memory, suggesting that the mPFC is one important site mediating the effects of D1 receptor stimulation on visual recognition memory.