Immunological alterations found in mesothelioma patients and supporting experimental evidence
Immunological alterations found in mesothelioma patients and supporting experimental evidence
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DOI：
10.1007/s12199-007-0012-y
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发表时间：
2008-03-01
影响因子：
4.7
通讯作者：
Otsuki, Takemi
中科院分区：
文献类型：
--
作者：
Miura, Yoshie;Nishimura, Yasumitsu;Otsuki, Takemi
众所周知，接触石棉会导致与石棉有关的疾病，如石棉沉滞症、肺癌和恶性间皮瘤，不仅在工作环境中长期接触石棉的人身上，而且在处理石棉的工厂附近居住的居民身上。自2005年夏天以来，这些披露变成了一个大的医疗问题，并引起了社会动荡。我们重点研究了石棉和二氧化硅对人体免疫系统的免疫学影响。在这篇简短的综述中，我们介绍了恶性间皮瘤患者的免疫学改变，并描述了这些发现的实验背景，分析石棉的免疫学效应可能会提高我们对石棉生物学效应的理解。
It is common knowledge that exposure to asbestos causes asbestos-related diseases, such as asbestosis, lung cancer and malignant mesothelioma, not only in people who have had long-term contact with asbestos in their work environment but also in residents living near factories that handle asbestos. Since the summer of 2005, these revelations turned into a large medical problem and caused and social unrest. We have focused on the immunological effects of both asbestos and silica on the human immune system. In this brief review, we introduce immunological alterations found in patients with malignant mesothelioma and describe the experimental background in which these were found. Analyzing the immunological effects of asbestos may improve our understanding of the biological effects of asbestos.