Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment.
Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment.
复制标题
白质超强度和灰质体积与认知障碍的老年人的认知相关性。
DOI：
10.1007/s00429-015-1034-7
复制
发表时间：
2016-05
影响因子：
3.1
通讯作者：
Bennett DA
中科院分区：
文献类型：
--
作者：
Arvanitakis Z;Fleischman DA;Arfanakis K;Leurgans SE;Barnes LL;Bennett DA
脑磁共振成像（MRI）显示白质高强度（WMH）和总灰质体积较小是老年人常见的发现，并有助于认知受损。我们测试了在没有痴呆或轻度认知障碍（MCI）的社区居住个体中，WMH总体积和灰质体积是否与认知有独立的关联。我们使用了拉什记忆和衰老项目参与者的数据。209名无痴呆或轻度认知损伤的受试者（平均年龄80岁，受教育程度为15年，74%为女性）进行了脑MRI检查。自动分割脑白质和脑灰质，测量脑白质和脑灰质总体积。两种mri测量结果均按颅内容积归一化。认知数据包括基于19个单独测试的五个不同认知领域的综合测量。采用线性回归分析，对年龄、性别和教育程度进行调整，以检验对数转换后的WMH总体积和灰质总体积与认知的关系。WMH总容量越大，感知速度水平越低（p < 0.001），但与情景记忆、语义记忆、工作记忆或视觉空间能力无关（均p < 0.10）。较小的灰质总体积与较低水平的感知速度（p = 0.013）和情景记忆（p = 0.001）相关，但与其他三个认知领域无关（p均为0.14）。WMH总体积越大，灰质总体积越小（p < 0.001）。在包含两种mri衍生测量的模型中，WMH与感知速度的关系仍然显著（p < 0.001），而灰质体积不再相关（p = 0.14）。这项研究对没有明显认知障碍的老年社区居民进行了研究，结果表明，较大的脑脑总容量与较低的感知速度之间的关联与脑灰质总体积无关。这些结果有助于阐明衰老导致认知功能下降的病理过程。
Both presence of white matter hyperintensities (WMH) and smaller total gray matter volume on brain magnetic resonance imaging (MRI) are common findings in old age, and contribute to impaired cognition. We tested whether total WMH volume and gray matter volume had independent associations with cognition in community-dwelling individuals without dementia or mild cognitive impairment (MCI). We used data from participants of the Rush Memory and Aging Project. Brain MRI was available in 209 subjects without dementia or MCI (mean age 80; education = 15 years; 74 % women). WMH and gray matter were automatically segmented, and the total WMH and gray matter volumes were measured. Both MRI-derived measures were normalized by the intracranial volume. Cognitive data included composite measures of five different cognitive domains, based on 19 individual tests. Linear regression analyses, adjusted for age, sex, and education, were used to examine the relationship of logarithmically-transformed total WMH volume and of total gray matter volume to cognition. Larger total WMH volumes were associated with lower levels of perceptual speed (p < 0.001), but not with episodic memory, semantic memory, working memory, or visuospatial abilities (all p > 0.10). Smaller total gray matter volumes were associated with lower levels of perceptual speed (p = 0.013) and episodic memory (p = 0.001), but not with the other three cognitive domains (all p > 0.14). Larger total WMH volume was correlated with smaller total gray matter volume (p < 0.001). In a model with both MRI-derived measures included, the relation of WMH to perceptual speed remained significant (p < 0.001), while gray matter volumes were no longer related (p = 0.14). This study of older community-dwelling individuals without overt cognitive impairment suggests that the association of larger total WMH volume with lower perceptual speed is independent of total gray matter volume. These results help elucidate the pathological processes leading to lower cognitive function in aging.