BEHAVIORAL AND ELECTROGRAPHIC PATTERNS INDUCED BY SYSTEMIC ADMINISTRATION OF KAINIC ACID IN DEVELOPING RATS
BEHAVIORAL AND ELECTROGRAPHIC PATTERNS INDUCED BY SYSTEMIC ADMINISTRATION OF KAINIC ACID IN DEVELOPING RATS
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DOI：
10.1016/0165-3806(83)90110-4
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
RICCI, GF
中科院分区：
文献类型：
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作者：
CHERUBINI, E;DEFEO, MR;RICCI, GF
Behavioral and electrographic changes induced by systemic injection of 3-6 mg/kg of kainic acid (KA) were studied during development in 1- to 28-day-old rats. In the 1st wk of life, a few minutes after the administration of the toxin, animals developed motor signs such as scratching movements, hypo- and hyperactivity, loss of postural control, tremors and hyperextension of the limbs. No changes of the electrical cortical and hippocampal activity were detected. Similar, but more accentuated, tumor signs occur when KA was injected during the 2nd wk of postnatal life. In this case, on the EEG, bursts of spikes or polispikes localized in the cortex appeared. These bursts became more and more frequent and after only 20 min spread to the hippocampus. No correlation between the electrical and behavioral changes was observed. By the 3rd wk of life, in addition to motor signs, systemic KA induced wet dog shakes (WDS) and limbic seizures. These were characterized by rearing, loss of postural control, masticatory movements and forepaw tremors. The EEG was characterized by primary hippocampal discharges that could spread to the cortex. Usually the limbic seizures become more and more frequent, leading to a status epilepticus. In another group of experiments, higher doses of KA (6-12 mg/kg) were injected in curarized and artificially respirated animals of the same age. During the 1st days of life (1-7), unlike in the corresponding group of freely moving animals, KA induced sequences of slow spikes localized in the cortex and after 10-20 min spread to the hippocampus. In the following age groups, no differences between the curarized and free moving animals were detected. The different sensitivity of systemic KA to induce limbic seizures in neonatal rats may be related to the immaturity of pre- and postsynaptic glutamergic receptors in the hippocampus. A different degree of maturity of cortical vs. hippocampal glutamergic receptors may account for the preferential activation of the cortex vs. hippocampus during the 1st period of life.
