SENSING DNA WITH ALTERNATING CURRENTS USING A NANOGAP SENSOR EMBEDDED IN A NANOCHANNEL DEVICE.

SENSING DNA WITH ALTERNATING CURRENTS USING A NANOGAP SENSOR EMBEDDED IN A NANOCHANNEL DEVICE.
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使用嵌入纳米通道设备中的纳米间隙传感器通过交流电感应 DNA。

DOI:
10.1142/s1793984413400072
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发表时间:
2013
期刊:
影响因子:
0.8
通讯作者:
Riehn,Robert
Riehn,Robert
中科院分区:
--
文献类型:
--
作者:
Davis,BretH;Pan,Junhan;Tung,Chih-Kuan;Austin,RobertH;Riehn,Robert

文献摘要

相似文献

我们报道了一种集成的纳米通道/纳米电极传感器,用于使用交流电检测DNA。我们发现,使用铂作为检测电极的金属可以检测到DNA,信噪比超过10。我们认为,这种信号至少在本质上是部分电化学的,因此有可能产生与序列相关的信号。然而,我们也发现,在大电压下,DNA不可逆转地附着在驱动电极上。
We report an integrated nanochannel/nanoelectrode sensor for the detection of DNA using alternating currents. We find that DNA can be detected using platinum as the metal for the detecting electrodes, with a signal to noise ratio exceeding 10. We argue that the signal is at least in part electrochemical in nature, thus holds the promise to yield a sequence-dependent signal. However, we also find that for large voltages, DNA attaches irreversibly to the driving electrodes.