Induction of long-term receptive field plasticity in the auditory cortex of the waking guinea pig by stimulation of the nucleus basalis
Induction of long-term receptive field plasticity in the auditory cortex of the waking guinea pig by stimulation of the nucleus basalis
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DOI：
10.1037/0735-7044.112.3.467
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发表时间：
1998-06-01
影响因子：
1.9
通讯作者：
Weinberger, NM
中科院分区：
文献类型：
--
作者：
Bjordahl, TS;Dimyan, MA;Weinberger, NM
学习诱发初级听皮层神经元感受野（RF）可塑性。这种可塑性构成了生理记忆，因为它是联想性的，高度特异性的，辨别性的，发展迅速的，并且无限期地保留。本研究探讨是否配对的音调与激活的基底核可以诱导RF可塑性在清醒的豚鼠，如果是这样的话，它是否可以保留24 hr.Subjects收到40个试验的一个单一的频率配对的电刺激的基底核（NB）在音调偏移。NE刺激的生理有效性随后在受试者用乌拉坦麻醉时通过观察刺激是否产生皮质去皮质化来评估。受试者中NE刺激是有效的RF可塑性，这是保留了24 hr.Thus，在正常学习过程中的NE激活可能足以诱导持久的生理记忆在听觉皮层。
Learning induces neuronal receptive field (RF) plasticity in primary auditory cortex. This plasticity constitutes physiological memory as it is associative, highly specific, discriminative, developes rapidly, and is retained indefinitely. This study examined whether pairing a tone with activation of the nucleus basalis could induce RF plasticity in the waking guinea pig and, if so, whether it could be retained for 24 hr. Subjects received 40 trials of a single frequency paired with electrical stimulation of the nucleus basalis (NB) at tone offset. The physiological effectiveness of NE stimulation was assessed later while subjects were anesthetized with urethane by noting whether stimulation produced cortical desynchronization. Subjects in which NE stimulation was effective did develop RF plasticity and this was retained for 24 hr. Thus, activation of the NE during normal learning may be sufficient to induce enduring physiological memory in auditory cortex.