Association between allergies and risk of pancreatic cancer.
Association between allergies and risk of pancreatic cancer.
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DOI：
10.1158/1055-9965.epi-13-0965
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Gallinger S
中科院分区：
文献类型：
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作者：
Cotterchio M;Lowcock E;Hudson TJ;Greenwood C;Gallinger S
不到10%的胰腺癌患者能存活5年，但其病因尚不清楚。研究表明，过敏与降低胰腺癌风险有关。我们的研究收集了关于过敏的额外信息（包括皮肤点刺试验结果和过敏性/非过敏性哮喘的区分），并且首次评估了过敏药物可能造成的混淆。一项基于人群的病例对照研究旨在全面评估过敏与胰腺癌风险之间的关系。胰腺癌病例是在2011-2012年期间诊断出来的，并通过安大略省癌症登记处确定（345例）。以人群为基础的对照组采用随机数字拨号和与病例匹配的年龄/性别频率确定（1285例对照）。问卷收集了终生过敏史（过敏类型、发病年龄、皮肤点刺试验结果）、过敏药物和已确定的胰腺癌危险因素。逻辑回归用于估计奇比和测试潜在的混杂因素，包括过敏药物。花粉热与胰腺癌风险的显著降低相关（AOR=0.68, 95% CI: 0.52-0.89），皮肤点刺试验花粉热过敏原阳性的患者风险降低幅度最大。在过敏的发病年龄和持续时间方面没有观察到特别的模式。粉尘/霉菌过敏皮肤点刺试验阳性和动物过敏与胰腺癌风险显著降低相关；AOR=0.49, 95% CI: 0.31-0.78； AOR=0.68, 95% CI: 0.46-0.99。哮喘与胰腺癌风险无关。这些发现支持了越来越多的证据，表明某些过敏与降低胰腺癌风险有关。
Less than 10% of pancreatic cancer cases survive five years, yet its etiology is not well understood. Studies suggest allergies are associated with reduced pancreatic cancer risk. Our study collected additional information on allergies (including skin prick test results and differentiation of allergic/non-allergic asthma), and is the first to assess possible confounding by allergy medications. A population-based case-control study was designed to comprehensively assess the association between allergy and pancreatic cancer risk. Pancreas cancer cases were diagnosed during 2011-2012, and identified through the Ontario Cancer Registry (345 cases). Population-based controls were identified using random digit dialing and age/sex frequency matched to cases (1285 controls). Questionnaires collected lifetime allergy history (type of allergy, age at onset, skin prick testing results), allergy medications, and established pancreas cancer risk factors. Logistic regression was used to estimate odd ratios and test potential confounders, including allergy medications. Hay fever was associated with a significant reduction in pancreatic cancer risk (AOR=0.68, 95% CI: 0.52-0.89), and reduction was greatest for those whose skin prick test was positive for hay fever allergens. No particular patterns were observed as regards age at onset and duration of allergy. Positive dust/mold allergy skin prick test and animal allergies were associated with a statistically significant reduced pancreatic cancer risk; AOR=0.49, 95% CI: 0.31-0.78 and AOR=0.68, 95% CI: 0.46-0.99, respectively. Asthma was not associated with pancreatic cancer risk. These findings support the growing body of evidence that suggests certain allergies are associated with reduced pancreatic cancer risk.