Altered electrophysiological correlates of motor inhibition and performance monitoring in Tourette’s syndrome
Altered electrophysiological correlates of motor inhibition and performance monitoring in Tourette’s syndrome
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DOI：
10.1016/j.clinph.2018.06.002
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发表时间：
2018-09
影响因子：
4.7
通讯作者：
T. Schüller;T. Gruendler;René J. Huster;J. Baldermann;D. Huys;M. Ullsperger;J. Kuhn
中科院分区：
文献类型：
--
作者：
T. Schüller;T. Gruendler;René J. Huster;J. Baldermann;D. Huys;M. Ullsperger;J. Kuhn
抽动秽语综合征（TS）的运动抑制能力是否受损仍无定论。抑制抽搐的能力已被提出，以确保正常的运动控制在简单的成年患者。采用事件相关电位（ERP）技术，对15例TS患者和15例正常对照者进行视觉停止信号任务，同时记录多通道EEG，研究TS患者和正常对照者的运动抑制和行为监测的皮层过程。P3的潜伏期是区分抑制成功的，在两组中成功抑制的潜伏期较短。P3振幅没有改变抑制成功，但TS患者显着衰减。此外，错误相关的负波（ERN）的幅度升高，而错误的正波（PE）减少了TS patients.ConclusionIn停止信号任务的性能是不改变的成年TS患者，但ERPs相关的运动抑制和性能监测的改变，建议潜在的补偿mechanism.SignificanceThe结果支持补偿皮层机制，以确保足够的运动性能的假设。
ObjectiveWhether motor inhibition capabilities are impaired in Tourette’s syndrome (TS) remains inconclusive. The ability to suppress tics has been proposed to ensure normal motor control in uncomplicated, adult patients. The aim of the present study was to characterize cortical processes of motor inhibition and performance monitoring using event-related potentials (ERPs) elicited by a visual stop signal task.Methods15 TS patients and 15 matched healthy controls performed a stop signal task while multi-channel EEG were recorded.ResultsThe behavioral results revealed no significant differences in inhibitory capabilities between groups. The latency of the P3 was discriminative of inhibition success, with shorter latencies for successful inhibition in both groups. P3 amplitude was not altered by inhibition success, but significantly attenuated for TS patients. Furthermore, the amplitude of the error-related negativity (ERN) was elevated while the error positivity (PE) was diminished for TS patients.ConclusionIn the stop signal task performance is not altered in adult TS patients but ERPs related to motor inhibition and performance monitoring are altered suggesting potential compensatory mechanisms.SignificanceThe results support the hypothesis of compensatory cortical mechanisms to ensure sufficient motor performance.