The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death
The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death
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DOI：
10.1515/cclm.2010.348
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发表时间：
2010-12-01
影响因子：
6.8
通讯作者：
Peng, Chung-Kang
中科院分区：
文献类型：
--
作者：
Lin, Yen-Hung;Lin, Chen;Peng, Chung-Kang
背景：心脏细胞外基质（ECM）纤维化在心力衰竭（HF）的病理生理中起着重要作用。它可能提供电不均匀性和致心律失常的基底，这可能导致心源性猝死（SCD）。方法：21例表现为HF且左室射血分数（LVEF） 20 ms (pNN20) （r=-0.545, p=0.002）、极低频（VLF） （r=-0.490, p=0.024）、低频（LF） （r=-0.491, p=0.024）、高频（HF） （r=-0.513, p=0.018）的患者。PINP、MMP-2、-9、TIMP-1与HRV的时频域分析无相关性。结论：PIIINP与HF患者HRV的时域和频域分析显著相关。PIIINP是评估心衰患者心脏自主控制和SCD风险的潜在血清学指标。临床化学实验室医学2010；48:1821-7。
Background: Cardiac extra-cellular matrix (ECM) fibrosis plays an important role in the pathophysiology of heart failure (HF). It may provide electrical heterogeneity and a substrate for arrhythmogenicity, which may cause sudden cardiac death (SCD).Methods: Twenty-one patients with manifestations of HF and a left ventricular ejection fraction (LVEF) 20 ms (pNN20) (r=-0.545, p=0.002), very low frequency (VLF) (r=-0.490, p=0.024), low frequency (LF) (r=-0.491, p=0.024), and high frequency (HF) (r=-0.513, p=0.018). PINP, MMP-2, -9, TIMP-1 were not correlated with time-and frequency-domain analysis of HRV.Conclusions: PIIINP was significantly correlated with time- and frequency-domain analysis of HRV in HF patients. PIIINP is a potential serological marker to evaluate cardiac autonomic control and risk of SCD in HF patients. Clin Chem Lab Med 2010; 48:1821-7.