Use of intravoxel incoherent motion MRI to assess placental perfusion in normal and Fetal Growth Restricted pregnancies on their third trimester
Use of intravoxel incoherent motion MRI to assess placental perfusion in normal and Fetal Growth Restricted pregnancies on their third trimester
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DOI：
10.1016/j.placenta.2021.12.019
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发表时间：
2022-01-04
期刊：
影响因子：
3.8
通讯作者：
Xu, Yi-Kai
中科院分区：
文献类型：
--
作者：
Liu, Xi-Long;Feng, Jie;Xu, Yi-Kai
前言：体素内非相干运动(IVIM)MRI是一种非侵入性的在体技术，可以定量评估胎盘的血流灌注，并有助于评估胎盘微循环。我们的主要目的是研究胎儿生长受限(FGR)妊娠与正常妊娠相比是否有不同的胎盘灌注和扩散。第二个目的是研究正常妊娠胎盘IVIM参数与胎龄的相关性。方法：研究对象为妊娠28+3~38+0周的FGR孕妇17例和正常孕妇36例。所有女性都接受了MRI检查，包括在3.0T MRI系统上使用9b值的IVIM序列。计算标准扩散系数(D)、假扩散系数(D*)和灌注分数(F)。结果：FGR组胎盘f显著低于正常组(33.96±2.62(%)vs 38.48±5.31(%)，P=0.002)。两组胎盘D、D*差异无统计学意义(P>；0.05)。正常妊娠胎盘f随胎龄增加呈中度升高(r=0.411，p=0.013)，胎盘D值与胎龄呈负相关(r=-0.390，p=0.019)。讨论：f值能够区分FGR和正常妊娠。可作为评价胎盘血流灌注的一项可行指标。胎盘IVIM参数与胎龄相关的变化可能揭示了正常发育胎盘的微血管灌注率和扩散特征的轨迹。
Introduction: Intravoxel Incoherent Motion (IVIM) MRI is a non-invasive, in vivo techniques which can assess placental perfusion quantitatively, and be useful for evaluating placental microcirculation. Our primary aim was to investigate whether fetal growth restriction (FGR) pregnancies have different placental perfusion and diffusion compared with normal pregnancies using IVIM. A secondary aim was to investigate correlations between placental IVIM parameters and gestational age in normal pregnancy. Methods: This study population included 17 FGR pregnancies and 36 normal pregnancies between 28 + 3 to 38 + 0 weeks. All women underwent a MRI examination including an IVIM sequence with 9 b-values on a 3.0 T MRI system. The standard diffusion coefficeint (D), pseudodiffusion (D*) and perfusion fraction (f) were calculated. Results: Placental f was significantly lower in the FGR group than that in the normal group (33.96 +/- 2.62(%) vs 38.48 +/- 5.31(%), p = 0.002). Placental D and D* in two groups showed no statistical significance (P > 0.05). Placental f moderately increased with increasing gestational age in normal pregnancies (r = 0.411, p = 0.013), and there existed a negative correlation between D values and gestational age (r = -0.390, p = 0.019). Discussion: The f values are able to distinguish FGR from normal pregnancies. It can be uses as a feasible index to evaluate placenta perfusion. Gestational age-associated changes in placental IVIM parameters likely reveal trajectories of microvascular perfusion fraction and diffusion characteristics in the normal developing placenta.