The impact of 5-year tumor doubling time to predict the subsequent long-term natural history of asymptomatic meningiomas.
The impact of 5-year tumor doubling time to predict the subsequent long-term natural history of asymptomatic meningiomas.
复制标题
5 年肿瘤倍增时间对预测无症状脑膜瘤后续长期自然史的影响。
DOI：
10.1016/j.wneu.2021.05.023
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发表时间：
2021
期刊：
影响因子：
2
通讯作者：
Kishima H.
中科院分区：
文献类型：
--
作者：
Yamada S;Kinoshita M;Nakagawa T;Hirayama R;Kijima N;Kagawa N;Kishima H.
脑膜瘤是最常见的原发性脑肿瘤。然而，无症状脑膜瘤的长期自然病程仍然不清楚，难以准确预测。本研究的目的是确定随后的过程中，无症状脑膜瘤之前5年没有treatment.MethodsWe回顾性研究患者与放射学怀疑无症状颅内脑膜瘤之前5年没有治疗。我们测量了病灶在最初5年内的时间变化，以获得5年肿瘤倍增时间（5 y-TdT）。他们被进一步分为3个亚组：无症状者（A组; 174例），出现神经系统症状并接受治疗者（B组; 8例），以及因预防原因接受故意干预者（C组; 19例）。B组5年TdT（中位数46.5个月）明显短于A组（中位数216.3个月）（P< 0.001）。5 y-TdT ≥ 98.8个月和<98.8个月的肿瘤无进展生存期（PFS）差异有统计学意义（P< 0.001）。当我们结合组B和C和PFS终点设置为疾病进展或治疗，我们发现，超过20%的患者将需要治疗15 years.ConclusionsThe本研究揭示了随后的过程中无症状脑膜瘤后5年的无治疗，并证明5年-TdT是有用的检测患者谁可能需要治疗。
ObjectiveMeningiomas are the most frequent primary brain tumors. The long-term natural history of asymptomatic meningiomas remains unclear and difficult to predict accurately, however. The purpose of this study was to determine the subsequent course of asymptomatic meningiomas preceded by 5 years of no treatment.MethodsWe retrospectively studied patients with radiologically suspected intracranial asymptomatic meningiomas preceded by 5 years of no treatment. We volumetrically measured the lesions' chronological changes during the initial 5 years to obtain the 5-year tumor doubling time (5y-TdT).ResultsA total of 201 cases met the inclusion criteria. They were further divided into 3 subgroups: those who remained asymptomatic (group A; 174 cases), those who developed neurological symptoms and underwent treatment (group B; 8 cases), and those who received intentional intervention for a preventative reason (group C; 19 cases). 5y-TdT of group B (median: 46.5 months) was significantly shorter than that of group A (median: 216.3 months) (P< 0.001). Progression-free survival (PFS) was significantly different between tumors that exhibited 5y-TdT ≥ 98.8 months and <98.8 months (P< 0.001). When we combined groups B and C and set the PFS endpoint as either disease progression or treatment, we found that more than 20% of patients would require treatment within 15 years.ConclusionsThe present study revealed the subsequent course of asymptomatic meningiomas after 5 years of no treatment and demonstrated that 5y-TdT is useful to detect patients who may require treatment.