INVESTIGATIONS ON EFFECTS OF CHRONIC CIGARETTE-SMOKE INHALATION IN SYRIAN GOLDEN-HAMSTERS
INVESTIGATIONS ON EFFECTS OF CHRONIC CIGARETTE-SMOKE INHALATION IN SYRIAN GOLDEN-HAMSTERS
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DOI：
10.1093/jnci/51.6.1781
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发表时间：
1973-01-01
影响因子：
10.3
通讯作者：
SCHNEIDER, B
中科院分区：
文献类型：
--
作者：
DONTENWILL, W;CHEVALIER, HJ;SCHNEIDER, B
报道了对叙利亚金黄地鼠的慢性吸入试验结果。在4440只仓鼠中，3610只被用于其整个生命周期；其余830只被暴露在不超过52周的环境中。一些动物接受了额外的致癌物治疗。存活时间、体重和器官重量的发育与治疗或形态变化有关。进行器官和组织的病理组织学检查、血液学检查和血液生化分析。实验结果显示出剂量-反应关系。评估了不同类型卷烟的烟雾效果以及烟雾和致癌物联合治疗的效果。结果如下：1)烟雾暴露-惊厥引起的变化在各实验组之间存在差异。改变最明显的是喉部，与治疗时间和剂量有关；存活时间缩短，体重减轻呈剂量依赖性；红细胞数量增加，血红蛋白上升。2)烟雾暴露增强的改变--“烟细胞”的发生率更高，“腺瘤样病变”的发生率略有增加。3)DMBA治疗效果：口腔、咽部、食道、胃、气管、肝脏、卵巢等部位肿瘤数量增加，卵巢囊肿发生率增加。4)亚硝胺治疗的效果--气管和喉下部的乳头状瘤不同于暴露在烟雾中的动物。5)与治疗无关的变化包括胃溃疡、胃炎、肺气肿、呼吸道炎症、全身性淀粉样变性、睾丸萎缩、血管和心脏病、肌肉萎缩、心和肺血栓的形成、心肌病、软组织和肠道器官的炎性改变、胆管囊肿、胆管增殖；以及鼻腔、皮肤、结缔组织和支持组织、造血系统和肾上腺的肿瘤，以及生化和血液学改变(不包括红细胞和血红蛋白的变化)。
Results of chronic inhalation experiments on Syrian golden hamsters were reported. Of 4440 hamsters, 3610 were used for their entire lifespans; the remaining 830 were exposed for no longer than 52 weeks. Some animals received additional treatment with carcinogens. Survival times and body and organ-weight development were correlatetl with treatment or morphologic changes. Pathohistologic investigations of organs and tissues, hematologic examinations, and biochemical analyses of blood were performed. Experimental results demonstrated a dose-response relationship. Effects of smoke from various types of cigarettes and effects of combined smoke and carcinogen treatment were evaluated. The results were as follows: 1) Changes induced by smoke exposure—Striking differences were found between experimental groups. Alterations were most pronounced in the larynx and depended on duration of treatment and dosage; survival times were reduced, and loss of body weight was dose dependent; the number of erythrocytes increased and hemoglobin rose. 2) Changes enhanced by smoke exposure-Incidence of “smoke cells” was greater; increase in “adenomatoid lesions” was slightly significant. 3) Effects of treatment with DMBA—The number of tumors increased in the oral cavity, pharynx, esophagus, stomach, trachea, liver, anti ovary; the occurrence of ovarian cysts also increased. 4) Effects of nitrosamine treatment—Papillomas in the trachea and lower region of the larynx differed from those in animals exposed to smoke. 5) Changes not connected with treatment—Findings included stomach ulcers, gastritis, pulmonary emphysema, inflammation of the respiratory tract, generalized amyloidosis, testicular atrophy, vascular and heart diseases, muscular atrophy, formation of thromboses in heart and lungs, cardiomyopathy, inflammatory changes in the soft tissue and intestinal organs, bile-duct cysts, bile-duct proliferation; also tumors of the nasal cavity, skin, connective and supporting tissues, hematopoietic system, and adrenal glands, and biochemical and hematologic changes (apart from changes in erythrocytes and hemoglobin).