Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status
Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status
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DOI：
10.1038/sj.ejcn.1601365
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发表时间：
2002-07-01
影响因子：
4.7
通讯作者：
O'Brien, PE
中科院分区：
文献类型：
--
作者：
Dixon, JB;Dixon, ME;O'Brien, PE
背景：适度饮酒与改善中年人的血管风险状况和降低死亡率有关。同型半胱氨酸浓度升高是心血管疾病的一个独立危险因素。目的：探讨严重肥胖患者（体重指数（BMI）> 35）饮酒与同型半胱氨酸浓度之间的关系。设计：从350例（男：女1：5）连续患者中获得一份仔细的饮酒史，作为肥胖手术治疗术前评估的一部分。获得的数据涉及饮酒的数量、频率、时间和类型。测定空腹同型半胱氨酸、血清叶酸和维生素B-12浓度。使用Student t检验和ANOVA评估组间差异。结果：饮酒量与同型半胱氨酸浓度呈U型关系，轻度至中度消费与较低的浓度相关。饮酒量< 100 g/周（n = 165）的人血清同型半胱氨酸浓度的几何平均值（平均值的95% CI）为8.5（8.2 - 8.9）μ mol/l，而非或罕见饮酒者为9.5（9.1 - 9.9）μ mol/l（n = 153; P = 0.001）。与非消费者7.5（7.1 - 7.8）ng/ml相比，普通消费者中同型半胱氨酸浓度较低，叶酸浓度较高（9.4（8.6 - 10.2）ng/ml）（P = 0.001）。红葡萄酒消费者（n = 42）空腹同型半胱氨酸浓度7.8（7.5 - 8.1）μ mol/l低于153名非消费者（9.4（9.0 - 9.8）μ mol/l）（P
Background: Moderate alcohol consumption is associated with improved vascular risk profile and decreased mortality in the middle aged. An elevated homocysteine concentration is an independent risk factor for cardiovascular disease.Objective: To examine the relationship between alcohol consumption and homocysteine concentrations in severely obese patients (body mass index (BMI) > 35).Design: A careful alcohol history was obtained from 350 (male: female 1 : 5) consecutive patients as part of preoperative assessment for surgical treatment of obesity. Data were obtained concerning amount, frequency, timing and type of alcohol consumption. Fasting homocysteine, serum folate and vitamin B-12 concentrations were measured. Differences between groups were assessed using Student t-test, and ANOVA. Linear regression was used to assess factors influencing homocysteine concentration.Results: There is a U-shaped relationship between alcohol consumption and homocysteine concentrations., with light to moderate consumption being associated with lower concentrations. Those consuming < 100 g/week (n = 165) of alcohol had geometric mean (95% CI of mean) serum homocysteine concentrations of 8.5 (8.2 - 8.9) mu mol/l compared with 9.5 (9.1 - 9.9) mu mol/l for non or rare consumers (n = 153; P = 0.001). The lower concentrations of homocysteine in regular consumers were associated with higher folate concentrations of 9.4 (8.6 - 10.2) ng/ml when compared with non-consumers 7.5 (7.1 - 7.8) ng/ml (P = 0.001). Red wine consumers (n = 42) had lower fasting concentrations of homocysteine 7.8 (7.5 - 8.1) mu mol/l compared with 153 non-consumers 9.4 (9.0 - 9.8) mu mol/l (P