"Sub is a weird drug:" A web-based study of lay attitudes about use of buprenorphine to self-treat opioid withdrawal symptoms.
"Sub is a weird drug:" A web-based study of lay attitudes about use of buprenorphine to self-treat opioid withdrawal symptoms.
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DOI：
10.1111/ajad.12213
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Sheth A
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文献类型：
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作者：
Daniulaityte R;Carlson R;Brigham G;Cameron D;Sheth A
丁丙诺啡的非法使用在美国有所增加，但我们对其使用的了解仍然有限。本研究旨在探讨网络论坛上关于使用丁丙诺啡自我治疗阿片类戒断症状的讨论。PREDOSE是一个新颖的语义网络平台，用于从一个允许自由讨论非法药物的网络论坛中提取相关帖子。首先，我们提取了2005 - 2013年间每年与丁丙诺啡相关的职位总数。其次，PREDOSE用于识别所有可能包含关于丁丙诺啡和阿片类药物戒断的讨论的帖子。共提取1217篇包含这些术语的文章，并输入NVivo数据库。随机选取404篇（33%）帖子进行内容分析。与丁丙诺啡相关的帖子随着时间的推移而增加，在2011年达到顶峰。对于丁丙诺啡缓解戒断症状的有效性，持积极和消极观点的帖子几乎平分秋色。网络论坛的参与者强调，丁丙诺啡的有效性可能会因为“个人习惯的大小”和/或当使用者反复在丁丙诺啡和其他非法阿片类药物之间来回切换而受到损害。大多数帖子报告说，丁丙诺啡的使用量（2毫克）明显低于标准治疗中使用的剂量。同时使用其他精神活性物质的情况也很普遍，这可能造成严重的健康风险。我们的发现强调了基于网络的数据在药物滥用研究中的有用性，并增加了关于丁丙诺啡的外行信念的新信息，这可能有助于为预防和政策措施提供信息。
Illicit use of buprenorphine has increased in the U.S., but our understanding of its use remains limited. This study aims to explore Web-forum discussions about the use of buprenorphine to self-treat opioid withdrawal symptoms. PREDOSE, a novel Semantic Web platform, was used to extract relevant posts from a Web-forum that allows free discussions on illicit drugs. First, we extract information about the total number of buprenorphine-related posts per year between 2005 and 2013. Second, PREDOSE was used to identify all posts that potentially contained discussions about buprenorphine and opioid withdrawal. A total number of 1,217 posts that contained these terms were extracted and entered into NVivo data base. A random sample of 404 (33%) posts was selected and content analyzed. Buprenorphine-related posts increased over time, peaking in 2011. The posts were about equally divided between those that expressed positive and negative views about the effectiveness of buprenorphine in relieving withdrawal symptoms. Web-forum participants emphasized that buprenorphine’s effectiveness may become compromised because of the “size of a person habit,” and/or when users repeatedly switch back and forth between buprenorphine and other illicit opioids. Most posts reported use of significantly lower amounts of buprenorphine ( 2 mg) than doses used in standard treatment. Concomitant use of other psychoactive substances was also commonly reported, which may present significant health risks. Our findings highlight the usefulness of Web-based data in drug abuse research and add new information about lay beliefs about buprenorphine that may help inform prevention and policy measures.