Novel Methods for Prevention and Early Diagnosis of Ovarian and Endometrial Cancers
Novel Methods for Prevention and Early Diagnosis of Ovarian and Endometrial Cancers
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DOI：
10.1007/978-3-319-32907-9_5
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Davis, Selina
中科院分区：
文献类型：
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作者：
Piccoli, Roberto;De Rosa, Nicoletta;Davis, Selina
由于子宫内膜癌发病率高，卵巢癌预后差，因此建立一套规范化的早期发现和诊断方法是当今肿瘤学研究的主要目标。基因组学和蛋白质组学的进展以及关于肿瘤行为及其特定特征的新发现引起了对几个新兴因素的关注，这些因素在未来可能成为妇科肿瘤学的特定诊断工具。遗传易感性与环境暴露之间的相互作用被认为是肿瘤发生、发展的主要致病因素之一。阐明调节这些相互作用的确切机制，以及参与肿瘤生长的细胞途径可以在识别“高危”人群方面做出重大贡献。针对性的诊断研究，选择人群最大限度地提高筛查计划的健康效益，以及非常重要的是，允许早期发现癌症仍然是肿瘤幸存者的主要积极预后因素。另一方面，有利于妇科肿瘤学的第二个研究领域是成像技术的不断改进。通过观察组织形态的特异性变化，可以早期识别肿瘤生长。妇科肿瘤成像的未来创新将超越解剖学，专注于功能。
Because of the high incidence of endometrial cancer and the to poor prognosis of ovarian cancer establish a standardized practice method in early detection and diagnosis of these gynecological tumors is nowadays a primary goal in oncology research. Genomics and proteomics advances and new discoveries about tumor behavior and its specific characteristics bring the attention on several emerging factors that in the next future could become specific diagnostics tool in gynecologic oncology. The interaction between the genetic predisposition and the environment exposure has been recognized as one of the main pathogenic moments of tumor's development and growth. Clarify the exact mechanism that regulates these interactions and the cellular pathways involved in tumor growth can substantially contribute in identify "high-risk" populations. To target diagnostic investigations, to selected populations maximizing health benefits of screening programs and, of great importance, to allow the early detection of cancers remain main positive prognostic factors in tumor survivors. On the other hand, the second area of study, which benefits gynecologic oncology, is the constant improvement of imaging techniques. The tumor growth is early recognized observing specific changes in tissue morphology. Future innovations in gynecologic-oncology imaging will go beyond anatomy to focus on function.