Marrying structure and genomics
Marrying structure and genomics
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DOI：
10.1016/s0969-2126(98)00029-x
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发表时间：
1998-03-15
期刊：
影响因子：
5.7
通讯作者：
Rost, B
中科院分区：
文献类型：
--
作者：
Rost, B
目的结构测定将在两个方面受益于基因组学(图1)。首先，大量的可用序列将有助于快速确定大多数现有褶皱的结构。其次，生物体全基因组序列的可获得性不仅有助于我们解开功能途径中缺失的环节，而且还有助于探索替代途径，并拓宽我们对主要机制和进化交叉链接的理解。
ObjectivesStructure determination will benefit from genomics in two ways (Figure 1). Firstly, the mass of available sequences will facilitate the quick determination of structure for most existing folds. Secondly, the availability of sequences for the entire genome of an organism will not only help us to unravel missing links in functional pathways, but also to explore alternative pathways and to widen our understanding of principle mechanisms and evolutionary cross-links.