Discharge patterns of Botzinger complex neurons during cough in the cat
Discharge patterns of Botzinger complex neurons during cough in the cat
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DOI：
10.1152/ajpregu.1998.274.4.r1015
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发表时间：
1998-04-01
影响因子：
2.8
通讯作者：
Pantaleo, T
中科院分区：
文献类型：
--
作者：
Bongianni, F;Mutolo, D;Pantaleo, T
本研究在戊巴比妥钠麻醉的自主呼吸猫上进行，以解决Botzinger复合体（BotC）神经元参与气管支气管树机械刺激诱导的咳嗽运动模式的产生的假设。监测膈神经和腹部肌肉活动以及颅内压;进行BotC神经元（n = 87）的单单位细胞外记录。大多数的增强呼气（E-Aug）神经元遇到（n = 47）显示兴奋性反应，在咳嗽的排出阶段与腹部爆发的主要成分和相应的气管压力的增加平行。我们还发现E-Aug神经元在咳嗽期间显著抑制直至完全抑制（n = 14），以及E-Aug神经元呈现递减模式，而没有任何增加，甚至其峰值活性有所降低（n = 15）。在呼气刺激过程中，大多数递减呼气神经元（n = 7）呈现兴奋性反应，而其他神经元则被抑制（n = 3）或完全抑制（n = 1）。结果是一致的，这些神经元参与咳嗽运动模式的产生，特别是，一些BotC E-Aug神经元传递兴奋性驱动尾部呼气神经元，因此，呼气运动神经元。
This study was carried out on pentobarbital sodium-anesthetized, spontaneously breathing cats to address the hypothesis that Botzinger complex (BotC) neurons are involved in the production of the cough motor pattern induced by mechanical stimulation of the tracheobronchial tree. Phrenic nerve and abdominal muscle activities as well as intratracheal pressure were monitored; single-unit extracellular recordings from BotC neurons (n = 87) were performed. The majority of augmenting expiratory (E-Aug) neurons encountered (n = 47) displayed excitatory responses during the expulsive phases of coughing in parallel with the main components of the abdominal bursts and the corresponding increases in tracheal pressure. We also encountered E-Aug neurons markedly depressed up to complete inhibition during coughing (n = 14) as well as E-Aug neurons assuming a decremental pattern without any increase or even with some reduction in their peak activity (n = 15). During the expiratory thrusts, most decrementing expiratory neurons (n = 7) presented excitatory responses, whereas others were depressed (n = 3) or completely inhibited (n = 1). The results are consistent with the view that these neurons are involved in the generation of the cough motor pattern and, in particular, that some BotC E-Aug neurons convey excitatory drive to caudal expiratory neurons and, hence, to expiratory motoneurons.