Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice
Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice
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DOI：
10.1007/s12011-019-02016-7
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发表时间：
2019-12-21
影响因子：
3.9
通讯作者：
Saleh, Hanan
中科院分区：
文献类型：
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作者：
Alharthi, Wed A.;Hamza, Reham Z.;Saleh, Hanan
镉（Cd）已被报道降低男性生育能力，损害生殖能力，并在不育症的发病机制中发挥重要作用。本研究旨在探讨硒（Se）和L-肉碱（LC）对镉（Cd）致雄性小鼠生殖系统损害的保护作用。动物随机分为7组（n = 10）：对照组和6个治疗组，如下：镉（0.35 mg/kg），硒（0.87 mg/kg），LC（10 mg/kg），硒或LC的组合，然后两者与镉的组合，所有动物注射为期30天。暴露的镉表现出显着下降的酶的抗氧化活性，生殖性能不足，血清睾酮水平下降，组织病理学结构的严重变化，以及更高程度的损害和外观的无瑕疵的DNA链。硒和维生素C具有高度的协同作用，通过提高酶的抗氧化能力，减轻组织病理学异常和DNA损伤，从而减轻镉对睾丸的损伤作用。
Cadmium (Cd) has been reported to reduce male fertility, impair reproductive capacity, and play a major role in the pathogenesis of infertility. This study was conducted to investigate the possible protective role of Selenium (Se) and L-carnitine (LC) against the adverse effects induced by Cd on the male reproductive system in mice. Animals were randomly divided into seven groups (n = 10); control group and six treated groups, as follows: Cd (0.35 mg/kg), Se (0.87 mg/kg), LC (10 mg/kg), and a combination of either Se or LC and then a combination of both with Cd, and all animals were injected for a period of 30 days. Exposure of Cd showed a significant decrease in enzymatic antioxidant activities, deficiency in reproductive performance, decrease serum testosterone level, severe changes in the histopathological architecture, and higher degree of damages and appearance of unblemished DNA strands. Treatment with Se and LC has the highly synergistic and ameliorates the damaging effect of Cd on the testis through the elevation of the enzymatic antioxidant and diminish histopathological abnormalities and DNA damage.