Decreased capillary permeability and capillary density in patients with systemic sclerosis using large-window sodium fluorescein videodensitometry of the ankle
Decreased capillary permeability and capillary density in patients with systemic sclerosis using large-window sodium fluorescein videodensitometry of the ankle
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DOI：
10.1093/rheumatology/ken248
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发表时间：
2008-09-01
期刊：
影响因子：
5.5
通讯作者：
Bootsma, H.
中科院分区：
文献类型：
--
作者：
Hettema, M. E.;Zhang, D.;Bootsma, H.
Objective.据报道，通过甲襞毛细血管镜检查评估时，SSc患者的局部毛细血管通透性增加。我们通过踝关节的大窗口荧光素视频密度测定法测量了临床上受影响较小的部位的毛细血管通透性。我们假设毛细血管通透性增加或渗漏是SSc的普遍现象。在38例SSc患者和20例健康对照者中进行了荧光素钠大窗口视频密度测定。毛细血管通透性表示为荧光素在皮肤毛细血管中出现后前7分钟内的平均相对光强度[I-av（7）]。毛细血管通透性（以I-av（7）表示）在SSc患者中显著降低（47.3 +/-15.0%vs 57.6 +/- 9.4%，P = 0.007），毛细血管密度也是如此（12 +/- 6/mm（2）vs 26 +/- 11/mm（2），P < 0.001）。多因素回归分析显示，SSc组与对照组之间I-vs（7）的差异与毛细血管密度、BMI和高密度脂蛋白胆固醇的差异有关。在踝关节水平，SSc患者的毛细血管通透性降低，与毛细血管密度降低有关。微血管参与SSc是广泛的，但没有证据表明增加毛细血管渗透性在个别毛细血管的水平作为一个普遍的现象。
Objective. Local capillary permeability in patients with SSc has been reported increased when assessed by nail-fold capillaroscopy. We measured capillary permeability at a clinically less affected site by using large-window fluorescein videodensitometry of the ankle. We hypothesized that increased capillary permeability or leakage is a generalized phenomenon in SSc.Methods. Large-window videodensitometry with sodium fluorescein was performed in 38 SSc patients and 20 healthy controls. Capillary permeability was expressed as the average relative light intensity over the first 7 min [I-av(7)] after appearance of fluorescein in skin capillaries.Results. Capillary permeability, expressed as I-av(7) was significantly decreased in patients with SSc (47.3 +/- 15.0% vs 57.6 +/- 9.4% in controls, P = 0.007), as was capillary density (12 +/- 6/mm(2) vs 26 +/- 11/mm(2), P < 0.001). Adjustment for capillary density in multivariate regression analysis demonstrated that differences in I-vs(7) between SSc patients and controls were related to differences in capillary density, BMI and high density lipoprotein cholesterol.Conclusion. At the level of the ankle decreased capillary permeability was found in SSc patients, related to decreased capillary density. Microvascular involvement in SSc is widespread, but no evidence was established for increased capillary permeability at the level of individual capillaries as a generalized phenomenon.