Circulating microRNAs in autoimmune thyroid diseases
Circulating microRNAs in autoimmune thyroid diseases
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DOI：
10.1111/cen.12432
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发表时间：
2014-08
影响因子：
3.2
通讯作者：
Hiroya Yamada;M. Itoh;I. Hiratsuka;S. Hashimoto
中科院分区：
文献类型：
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作者：
Hiroya Yamada;M. Itoh;I. Hiratsuka;S. Hashimoto
自身免疫性甲状腺疾病（AITDs）包括Graves病（GD）和桥本甲状腺炎（HT），是最常见的自身免疫性疾病。microRNAs（miRNAs）是一类小分子非编码RNA，在免疫功能和自身免疫的发生发展中起着重要作用。近年来，人们认识到循环miRNA的鉴定可以提供关于疾病发病机制和临床状况的重要和新颖的信息。然而，循环miRNA在AITD中的作用尚未被描述。
Autoimmune thyroid diseases (AITDs), including Graves’ disease (GD) and Hashimoto's thyroiditis (HT), are the most common autoimmune diseases. MicroRNAs (miRNAs) are small noncoding RNAs, which can play pivotal roles in immune functions and development of autoimmunity. Recently, it has been recognized that identification of circulating miRNAs can provide important and novel information regarding disease pathogenesis and clinical condition. However, the role circulating miRNAs in AITD has not yet been described.