Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
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DOI：
10.1016/j.ijrobp.2018.04.026
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发表时间：
2018-08-01
期刊：
影响因子：
--
通讯作者：
Duda DG
中科院分区：
文献类型：
--
作者：
Grassberger C;Hong TS;Hato T;Yeap BY;Wo JY;Tracy M;Bortfeld T;Wolfgang JA;Eyler CE;Goyal L;Clark JW;Crane CH;Koay EJ;Cobbold M;DeLaney TF;Jain RK;Zhu AX;Duda DG
Radiation may have significant immuno-modulatory effects that impact tumor response and could potentiate immunotherapeutic approaches. The purpose of this study was to prospectively investigate circulating lymphoid cell population (CLP) fractions during hypofractionated proton therapy (HPT) in blood samples of liver cancer patients, and to explore their association with survival. We collected serial blood samples pre-treatment and at days 8 and 15 of HPT from 43 liver cancer—22 hepatocellular carcinoma (HCC) and 21 intrahepatic cholangiocarcinoma (ICC) —patients enrolled in a phase II clinical trial. All patients received 15 fractions of proton therapy to a median dose of 58 Gy (RBE). We used flow cytometry to measure the changes in the fractions of total CD3+, CD4+ and CD8+ T cells, CD4+CD25+ T cells, CD4+CD127+ T cells, CD3+CD8+CD25+ activated cytotoxic T lymphocytes (CTLs) and CD3–CD56+ natural killer (NK) cells. With a median follow-up of 42 months, median overall survival (OS) in the study cohort was 30.6 months for HCC and 14.5 months for ICC patients. Longer OS was significantly correlated with greater CD4+CD25+ T cell (p=0.003) and CD4+CD127+ T cell (p=0.01) fractions at baseline only in ICC patients. In HCC patients, the fraction of activated CTLs mid-treatment (at day 8) was significantly associated with OS (p=0.007). These findings suggest a differential relevance of immuno-modulation by HPT in these liver cancers. Anti-tumor immunity may depend on maintenance of a sufficiently high number of activated CTLs during HPT in HCC patients, and CD4+CD25+ T cells and CD4+CD127+ T cells prior to treatment in ICC patients. These results could guide the design of future studies to determine the optimal treatment schedules when combining radiation with specific immunotherapy approaches.
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影响因子：
28.5
作者：
Long J;Lin J;Wang A;Wu L;Zheng Y;Yang X;Wan X;Xu H;Chen S;Zhao H
通讯作者：
Zhao H
影响因子：
3.7
作者：
Young KH;Baird JR;Savage T;Cottam B;Friedman D;Bambina S;Messenheimer DJ;Fox B;Newell P;Bahjat KS;Gough MJ;Crittenden MR
通讯作者：
Crittenden MR
影响因子：
3.9
作者：
Chi, KW;Liu, SD;Hsieh, SL
通讯作者：
Hsieh, SL
DOI：
10.1016/j.ijrobp.2015.11.026
发表时间：
2016-03-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Wild AT;Herman JM;Dholakia AS;Moningi S;Lu Y;Rosati LM;Hacker-Prietz A;Assadi RK;Saeed AM;Pawlik TM;Jaffee EM;Laheru DA;Tran PT;Weiss MJ;Wolfgang CL;Ford E;Grossman SA;Ye X;Ellsworth SG
通讯作者：
Ellsworth SG
影响因子：
5
作者：
Cao, Mengde;Cabrera, Roniel;Nelson, David R.
通讯作者：
Nelson, David R.