Ventral striatum and stuttering: Robust evidence from a case-control study applying DARTEL
Ventral striatum and stuttering: Robust evidence from a case-control study applying DARTEL
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DOI：
10.1016/j.nicl.2019.101890
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发表时间：
2019-06
期刊：
影响因子：
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通讯作者：
C. Montag;Benjamin Bleek;M. Reuter;Thilo Müller;B. Weber;J. Faber;S. Markett
中科院分区：
文献类型：
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作者：
C. Montag;Benjamin Bleek;M. Reuter;Thilo Müller;B. Weber;J. Faber;S. Markett
发育性口吃的一个重要理论突出了基底节(尤其是腹侧纹状体)的功能，认为它是这种语言障碍背后的主要神经机制。尽管这一理论耐人寻味，但关于口吃者和对照组之间基底节灰质体积差异的研究报告了不同的发现，要么显示出前述大脑结构在大脑两个半球的灰质体积。此外，一些研究根本没有观察到任何差异。从今天的角度来看，早期的几项研究力度较小，也使用不太强大的统计方法来调查口吃者和对照组之间大脑结构的差异。因此，本研究对比了n= 36名口吃者和n= 34名对照组的样本，并应用最先进的Dartel算法(通过扩展李代数进行微分解剖配准)来分析可用的脑数据。在目前的数据集中，口吃与患者右侧基底节尾状核和壳核区的灰质体积较高有关。我们的观察有力地支持了最近的一项发现，与对照组相比，口吃者右脑伏隔核更大。目前的发现是在大脑的代偿效应和口吃治疗的假定治疗效果的背景下讨论的。
A prominent theory of developmental stuttering highlights (dys-)function of the basal ganglia (and in particular the ventral striatum) as a main neural mechanism behind this speech disorder. Although the theory is intriguing, studies on gray matter volume differences in the basal ganglia between people who stutter and control persons have reported heterogeneous findings, either showing more or less gray matter volume of the aforementioned brain structure across the brain's hemispheres. Moreover, some studies did not observe any differences at all.From today's perspective several of the earlier studies are rather underpowered and also used less powerful statistical approaches to investigate differences in brain structure between people who stutter and controls. Therefore, the present study contrasted a comparably larger sample ofn= 36 people who stutter withn= 34 control persons and applied the state of the art DARTEL algorithm (Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra) to analyze the available brain data. In the present data set stuttering was associated withhighergray matter volume of the right caudate and putamen region of the basal ganglia in patients. Our observation strongly supports a recent finding reporting a larger nucleus accumbens in the right hemisphere in people who stutter when compared to control persons. The present findings are discussed in the context of both compensatory effects of the brain and putative therapeutic effects due to treatment of stuttering.