Transplantation of fetal liver tissue coated by ultra-purified alginate gel over liver improves hepatic function in the cirrhosis rat model
Transplantation of fetal liver tissue coated by ultra-purified alginate gel over liver improves hepatic function in the cirrhosis rat model
复制标题
DOI：
10.1038/s41598-020-65069-y
复制
发表时间：
2020-05-19
影响因子：
4.6
通讯作者：
Taniguchi, Hideki
中科院分区：
文献类型：
--
作者：
Qiu, Rong;Murata, Soichiro;Taniguchi, Hideki
在本研究中，我们使用了一种新的包衣剂，即超纯化海藻酸盐凝胶（UPAL），用于胎儿肝组织移植。本研究旨在比较UPAL与其他包衣剂对肝硬化大鼠模型胎儿肝组织移植效果的改善作用。在野生型ED14胎肝组织移植前，分别在肝硬化大鼠肝表面涂敷各种包衣剂。然后比较移植面积、移植率和肝功能水平。由此可见，在肝硬化大鼠肝表面涂覆UPAL，在移植肝组织的植入面积、植入率及肝功能恢复方面均较对照组效果最佳。因此，UPAL涂层可作为肝类器官移植的新策略。
In this study, we used a new coating agent, that is, ultra-purified alginate gel (UPAL), for fetal liver tissue transplantation. This study aims to compare the effect of UPAL with the effect of other coating agents on improving the effect of fetal liver tissue transplantation in a liver cirrhosis rat model. Prior to the transplantation of wild-type ED14 fetal liver tissues, various coating agents were separately applied on the liver surface of rats with cirrhosis. Then, we compared the engraftment area, engraftment rate and liver function level of these rats. As a result, coating the liver surface of a cirrhosis rat with UPAL obtained the best effect in terms of engraftment area and engraftment rate of the transplanted liver tissue and in the recovery of liver function compared with control group. Therefore, UPAL coating may serve as a novel strategy for liver organoid transplantation.