Poly[oligo(2-ethyl-2-oxazoline) methacrylate] as a surface modifier for bioinertness
Poly[oligo(2-ethyl-2-oxazoline) methacrylate] as a surface modifier for bioinertness
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聚[低聚(2-乙基-2-恶唑啉)甲基丙烯酸酯]作为生物惰性表面改性剂
DOI：
10.1038/s41428-020-00459-7
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发表时间：
2021
期刊：
影响因子：
2.8
通讯作者：
Tanaka Keiji
中科院分区：
文献类型：
--
作者：
Hong Jin-Hyeok;Totani Masayasu;Kawaguchi Daisuke;Yamada Norifumi L.;Matsuno Hisao;Tanaka Keiji
对多功能高分子材料进行表面改性，在不改变其本体性质的前提下，是调节其物理、化学性质的基本技术之一，可以改善材料的功能。在这项研究中，瓶刷型聚[寡（2-乙基-2-恶唑啉）甲基丙烯酸酯]（P[O（Ox）nMA]）（n= 7和19）作为表面改性剂的合成。该化合物混合到聚（甲基丙烯酸甲酯）（PMMA）作为基质（PMMA/P[O（Ox）nMA]）的重量比为15%，并在空气和水环境下，通过原子力显微镜，接触角测量，角度依赖的X射线光电子能谱，和中子反射率在表面区域的聚集状态进行了检查。PMMA/P[O（Ox）nMA]薄膜的表面平整，并被富PMMA相覆盖。然而，一旦膜接触水，由于P[O（Ox）nMA]的迁移，表面被重组。由于熵因子的影响，P[O（Ox）7 MA]的表面偏析程度比P[O（Ox）19 MA]更显著。同时，P[O（Ox）7 MA]对NIH 3 T3成纤维细胞粘附和血清蛋白吸附的抑制作用比P[O（Ox）19 MA]更强，因为P[O（Ox）19 MA]在膜中与水形成了较厚的扩散界面。
Surface modification of versatile polymeric materials without changing their bulk properties is one of the essential techniques for regulating their physical and chemical characteristics, and this technique can improve the functions of materials. In this study, a bottlebrush-type poly[oligo(2-ethyl-2-oxazoline) methacrylate] (P[O(Ox)nMA]) (n= 7 and 19) was synthesized as a surface modifier. This compound was mixed into poly(methyl methacrylate) (PMMA) as a matrix (PMMA/P[O(Ox)nMA]) with a weight ratio of 15%, and the aggregation state in the surface region was examined under air and aqueous environments via atomic force microscopy, contact angle measurement, angular-dependent X-ray photoelectron spectroscopy, and neutron reflectivity. The surface of the PMMA/P[O(Ox)nMA] films was flat at the subnanometer level and covered with the PMMA-rich phase. However, once the films contacted water, the surface was reorganized due to the migration of P[O(Ox)nMA]. The extent of the surface segregation was more remarkable for P[O(Ox)7MA] than P[O(Ox)19MA] due to the entropic factor. Concurrently, NIH3T3 fibroblast adhesion and serum protein adsorption on the film were more strongly suppressed for P[O(Ox)7MA] than P[O(Ox)19MA] because it formed a thicker diffused interface in the film with water.
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发表时间：
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