Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy
Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy
复制标题
混合纳米平台：通过双模态成像引导光动力/化学/免疫协同治疗实现精确的抗肿瘤策略
DOI：
10.1021/acsnano.1c09635
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发表时间：
2021-12-08
期刊：
影响因子：
17.1
通讯作者：
Chang, Yulei
中科院分区：
文献类型：
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作者：
Chen, Haoran;Wu, Fengxia;Chang, Yulei
光动力疗法（PDT）因其高时空控制性和无创性在肿瘤治疗中得到广泛应用。但其疗效弱、组织渗透浅、光毒性等限制了其临床应用。本文设计了一种基于可光切换镧系掺杂纳米粒子的简易治疗纳米平台。通常，这些纳米粒子在980 nm激发下具有紫外蓝色和1525 nm发射，在800 nm激发下具有1525 nm发射。我们进一步使用这些纳米颗粒实现了实时近红外(NIR)-1Ib成像（800 nm），具有高信噪比和成像引导PDT （980 nm）。此外，这种光敏的纳米平台覆盖了ph敏感的磷酸钙，用于加载阿霉素（一种化疗免疫原性细胞死亡[ICD]诱导剂）和顺磁性的Mn2+离子，增强了肿瘤微环境中的t -i磁共振成像。我们的研究结果表明，这种治疗纳米平台不仅可以通过双模式图像引导的PDT/化疗直接杀死肿瘤细胞，还可以通过ICD抑制远处肿瘤和肺转移。因此，具有很大的临床应用潜力。
Photodynamic therapy (PDT) has been widely used in tumor therapy due to its high spatial-temporal control and noninvasiveness. However, its clinical application is limited by weak efficacy, shallow tissue penetration, and phototoxicity. Herein, a facile theranostic nanoplatform based on photoswitchable lanthanide-doped nanoparticles was designed. Typically, these nanoparticles had UV-blue and 1525 nm emission upon 980 nm excitation and 1525 nm emission upon 800 nm excitation. We further used these nanoparticles for achieving real-time near-infrared (NIR)-1Ib imaging (800 nm) with a high signal-to-noise ratio and imaging-guided PDT (980 nm). Moreover, such a photoswitchable nanoplatform capping with pH-sensitive calcium phosphate for coloading doxorubicin (a chemotherapeutic immunogenic cell death [ICD] inducer) and paramagnetic Mn2+ ions enhances T-i-magnetic resonance imaging in the tumor microenvironment. Our results suggest that this theranostic nanoplatform could not only kill tumor cells directly through dual-modal image-guided PDT/chemotherapy but also inhibit distant tumor and lung metastasis through ICD. Therefore, it has great potential for clinical application.