Toward 959 nematode genomes.
Toward 959 nematode genomes.
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DOI：
10.4161/worm.19046
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Blaxter M
中科院分区：
文献类型：
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作者：
Kumar S;Koutsovoulos G;Kaur G;Blaxter M
线虫秀丽隐杆线虫的全基因组测序是一项具有里程碑意义的成就，并开创了一个新时代的整体生物，系统分析的生物学这种强大的模式生物。C.线虫基因组测序项目也启发了研究其他生物的社区对其物种进行基因组测序。线虫动物门是一个丰富多样的研究领域，从基础生物学到生态学和寄生虫病。对于所有这些社区来说，现在很明显，获得基因组规模的数据将是促进理解的关键，对于寄生虫来说，开发控制或治愈疾病的新方法。第二代测序技术的出现、计算算法和基础设施的改进以及生物信息学和基因组学知识的增长，使得将基因组测序添加到任何线虫研究计划的研究目标中变得不那么令人畏惧的前景。为了激励、促进和协调整个线虫门的基因组测序，我们启动了一个社区维基和959个线虫基因组计划（www.nematodegenomes.org/）。正如对成年雌雄同体的C。虽然线虫是生物医学科学取得广泛进展的门户，但我们希望（至少）959个已测序物种的线虫发生学将支持进一步了解寄生虫的起源，基因组变化的动力学以及使线虫成为最成功的动物门之一的适应性。
The sequencing of the complete genome of the nematode Caenorhabditis elegans was a landmark achievement and ushered in a new era of whole-organism, systems analyses of the biology of this powerful model organism. The success of the C. elegans genome sequencing project also inspired communities working on other organisms to approach genome sequencing of their species. The phylum Nematoda is rich and diverse and of interest to a wide range of research fields from basic biology through ecology and parasitic disease. For all these communities, it is now clear that access to genome scale data will be key to advancing understanding, and in the case of parasites, developing new ways to control or cure diseases. The advent of second-generation sequencing technologies, improvements in computing algorithms and infrastructure and growth in bioinformatics and genomics literacy is making the addition of genome sequencing to the research goals of any nematode research program a less daunting prospect. To inspire, promote and coordinate genomic sequencing across the diversity of the phylum, we have launched a community wiki and the 959 Nematode Genomes initiative (www.nematodegenomes.org/). Just as the deciphering of the developmental lineage of the 959 cells of the adult hermaphrodite C. elegans was the gateway to broad advances in biomedical science, we hope that a nematode phylogeny with (at least) 959 sequenced species will underpin further advances in understanding the origins of parasitism, the dynamics of genomic change and the adaptations that have made Nematoda one of the most successful animal phyla.