Development and External Validation of a Nomogram Predicting the Probability of Significant Gleason Sum Upgrading among Japanese Patients with Localized Prostate Cancer.
Development and External Validation of a Nomogram Predicting the Probability of Significant Gleason Sum Upgrading among Japanese Patients with Localized Prostate Cancer.
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对日本局部前列腺癌患者中明显升级Gleason总和升级的可能性的开发和外部验证。
DOI：
10.1155/2011/754382
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发表时间：
2011
期刊：
影响因子：
4.2
通讯作者：
Ichikawa T
中科院分区：
文献类型：
--
作者：
Imamoto T;Utsumi T;Takano M;Komaru A;Fukasawa S;Suyama T;Kawamura K;Kamiya N;Miura J;Suzuki H;Ueda T;Ichikawa T
Objective.本研究的目的是开发一种预后模型，能够预测日本患者的显着升级的概率。 方法.研究队列包括508名接受RP治疗的男性，具有可用的前列腺特异性抗原水平、活检和RP Gleason总和值。从另一家日本机构获得了258例患者的临床和病理数据进行验证。 结果RP组92例患者（18.1%）的Gleason总和显著升高。诺模图预测活检和RP标本之间显著Gleason和升级概率的准确性为88.9%。应用于验证数据集时，总体AUC为0.872。诺模图预测的显着升级是在7.5%的理想诺模图。 结论.近五分之一的日本前列腺癌患者将明显升级。我们的列线图似乎提供了相当准确的预测，无论在病理评估的微小变化时，适用于日本患者人群。
Objective. The aim of this study is to develop a prognostic model capable of predicting the probability of significant upgrading among Japanese patients. Methods. The study cohort comprised 508 men treated with RP, with available prostate-specific antigen levels, biopsy, and RP Gleason sum values. Clinical and pathological data from 258 patients were obtained from another Japanese institution for validation. Results. Significant Gleason sum upgrading was recorded in 92 patients (18.1%) at RP. The accuracy of the nomogram predicting the probability of significant Gleason sum upgrading between biopsy and RP specimens was 88.9%. Overall AUC was 0.872 when applied to the validation data set. Nomogram predictions of significant upgrading were within 7.5% of an ideal nomogram. Conclusions. Nearly one-fifth of Japanese patients with prostate cancer will be significantly upgraded. Our nomogram seems to provide considerably accurate predictions regardless of minor variations in pathological assessment when applied to Japanese patient populations.