Taste in chimpanzees .2. Single chorda tympani fibers
Taste in chimpanzees .2. Single chorda tympani fibers
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DOI：
10.1016/s0031-9384(96)00562-8
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发表时间：
1997-06-01
影响因子：
2.9
通讯作者：
Danilova, V
中科院分区：
文献类型：
--
作者：
Hellekant, G;Ninomiya, Y;Danilova, V
本文报道了10只黑猩猩在29种刺激刺激下，鼓索神经中48条味觉纤维的数据。结果表明，味觉纤维比任何其他哺乳动物物种都具有更高的味觉纤维特异性；调谐宽度等于0.3。系统聚类分析分离出S簇(占所有纤维的50%)、N簇(31%)和Q簇(19%)。S聚类群的特异性最高。几乎没有例外，它的纤维对每一种测试的甜味剂都有反应，包括甜蛋白Brazzein和Monellin。这种反应随着甜味剂浓度的增加而增加。对一种甜味剂的大反应通常伴随着对所有其他甜味剂的大反应，反之亦然。除了一种宽调的纤维外，S簇的纤维对苦味化合物都没有反应。Q团簇的纤维比任何其他纤维都有更宽的调谐。盐酸奎宁的刺激效果最好，但大多数纤维也能被氯化钾和氯化钠加阿米洛利刺激。酸刺激了其中一些纤维。N亚群可分为3个亚群：安娜亚群(3根纤维)、Na-K亚群(10根纤维)和M亚群(3根纤维)。Na-纤维对氯化钠和氯化锂刺激反应强烈，且对氯化钾刺激有很强的特异性，Na-K亚簇的纤维对氯化钠和氯化钾反应同样好。阿米洛利抑制Na-亚团簇纤维对氯化钠的反应，但不抑制Na-K亚团簇纤维对氯化钠的反应。鲜味化合物在M-亚团簇中的反应最强。(C)1997年爱思唯尔科学公司。
Data are presented from 48 taste fibers in chorda tympani nerves of 10 chimpanzees during taste stimulation with 29 stimuli. The results demonstrated a higher taste fiber specificity than in any other mammalian species reported; breadth of tuning equals 0.3. Hierarchical cluster analysis separated an S-cluster (50% of all fibers), an N-cluster (31%), and a Q-cluster (19%). The S-cluster showed the highest specificity. Its fibers responded, with few exceptions, to every sweetener tested, including the sweet proteins brazzein and monellin. The response grew with increasing sweetener concentration. A large response to one sweetener was generally accompanied by a large response to all other sweeteners, and vice versa. Except for one broadly tuned fiber, the fibers of the S-cluster never responded to the bitter compounds. The fibers of the Q-cluster were more broadly tuned than any other fibers. Quinine hydrochloride was their best stimulus, but most fibers were also stimulated by KCl and NaCl with amiloride. Acids stimulated some of these fibers. The N-cluster could be divided into 3 subclusters: an Na-subcluster (3 fibers), Na-K subcluster (10 fibers), and M-subcluster (3 fibers). The Na-fibers responded strongly to, and were quite specific to, NaCl and LiCl stimulation but not to KCl, and fibers of the Na-K subcluster responded equally well to NaCl and KCl. The response to NaCl was suppressed by amiloride in the fibers of the Na-subcluster, but not in the fibers of the Na-K subcluster. Umami compounds elicited the strongest responses in the M-subcluster. (C) 1997 Elsevier Science Inc.