Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids.
Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids.
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DOI：
10.1016/j.apsb.2015.01.001
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Dawson PA
中科院分区：
文献类型：
--
作者：
Ferrebee CB;Dawson PA
胆汁酸的经典功能包括充当洗涤剂以促进肠道中营养物质的消化和吸收。此外，胆汁酸还作为信号分子调节葡萄糖稳态、脂质代谢和能量消耗。胆汁酸在诸如体循环的隔室中的信号传导潜力部分地由有效的肠肝循环调节，所述肠肝循环起到保存和引导肠和肝胆隔室内的胆汁酸池的作用。肝胆和肠胆汁酸转运的变化可以改变胆汁酸池的组成、大小和分布。这些改变反过来可以对胆汁酸信号传导及其下游代谢靶点产生显著影响。这篇综述讨论了最近的进展，我们的理解之间的相互关系的肝肠循环的胆汁酸和通过胆汁酸激活受体，如法尼醇X核受体（FXR）和G-蛋白偶联胆汁酸受体（TGR 5）的信号转导的代谢后果。这篇综述讨论了我们对胆汁酸的肝肠循环和通过胆汁酸激活的受体如法尼醇X核受体（FXR）和G蛋白偶联胆汁酸受体（TGR 5）的信号传导的代谢后果之间的相互关系的理解的最新进展。
The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy expenditure. The signaling potential of bile acids in compartments such as the systemic circulation is regulated in part by an efficient enterohepatic circulation that functions to conserve and channel the pool of bile acids within the intestinal and hepatobiliary compartments. Changes in hepatobiliary and intestinal bile acid transport can alter the composition, size, and distribution of the bile acid pool. These alterations in turn can have significant effects on bile acid signaling and their downstream metabolic targets. This review discusses recent advances in our understanding of the inter-relationship between the enterohepatic cycling of bile acids and the metabolic consequences of signaling via bile acid-activated receptors, such as farnesoid X nuclear receptor (FXR) and the G-protein-coupled bile acid receptor (TGR5). This review discusses recent advances in our understanding of the inter-relationship between the enterohepatic cycling of bile acids and the metabolic consequences of signaling via bile acid-activated receptors such as farnesoid X nuclear receptor (FXR) and the G-protein-coupled bile acid receptor (TGR5).