Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis
Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis
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嗅外间充质干细胞具有免疫调节功能并抑制自身免疫性关节炎
DOI：
10.1038/cmi.2015.82
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发表时间：
2016-05-01
影响因子：
24.1
通讯作者：
Wang, Shengjun
中科院分区：
文献类型：
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作者：
Rui, Ke;Zhang, Zhijiang;Wang, Shengjun
最近的研究发现嗅外间充质干细胞（OE-MSCs）是嗅觉固有层中的一种新型常驻干细胞。然而，目前尚不清楚OE-MSCs是否具有任何免疫调节功能。在这项研究中，我们发现小鼠 OE-MSC 比骨髓来源的 MSC 表达更高的转化生长因子-β 和白介素-10 水平。在培养中，OE-MSC 通过直接抑制效应 T 细胞增殖和增加调节性 T (Treg) 细胞扩增来发挥其免疫抑制能力。在患有胶原诱导关节炎的小鼠中，OE-MSC 的过继转移显着抑制了关节炎的发作和疾病的严重程度，同时伴随着体内 Treg 细胞的增加和 Th1/Th17 细胞反应的减少。综上所述，我们的研究结果确定了 OE-MSC 在调节 T 细胞反应方面的新功能，表明 OE-MSC 可能代表一种治疗类风湿关节炎和其他自身免疫性疾病的新细胞疗法。
Recent studies have identified olfactory ecto-mesenchymal stem cells (OE-MSCs) as a new type of resident stem cell in the olfactory lamina propria. However, it remains unclear whether OE-MSCs possess any immunoregulatory functions. In this study, we found that mouse OE-MSCs expressed higher transforming growth factor-beta and interleukin-10 levels than bone marrow-derived MSCs. In culture, OE-MSCs exerted their immunosuppressive capacity via directly suppressing effector T-cell proliferation and increasing regulatory T (Treg) cell expansion. In mice with collagen-induced arthritis, adoptive transfer of OE-MSCs markedly suppressed arthritis onset and disease severity, which was accompanied by increased Treg cells and reduced Th1/Th17 cell responses in vivo. Taken together, our findings identified a novel function of OE-MSCs in regulating T-cell responses, indicating that OE-MSCs may represent a new cell therapy for the treatment of rheumatoid arthritis and other autoimmune diseases.