Impaired working memory performance in opioid-dependent patients is related to reduced insula gray matter volume: a voxel-based morphometric study
Impaired working memory performance in opioid-dependent patients is related to reduced insula gray matter volume: a voxel-based morphometric study
复制标题
DOI：
10.1007/s00406-019-01052-7
复制
发表时间：
2021-08-01
影响因子：
4.7
通讯作者：
Hermann, Derik
中科院分区：
文献类型：
--
作者：
Bach, Patrick;Frischknecht, Ulrich;Hermann, Derik
阿片类药物依赖患者经常表现出多个认知领域的缺陷，这可能会影响他们的日常生活表现并干扰治疗工作。迄今为止，这些缺陷的神经生物学基础仍有待确定。我们使用磁共振成像和基于体素的形态测量法研究了17名阿片类药物维持治疗（OMT）患者和17名健康人的工作记忆表现和灰质体积（GMV）差异。此外，我们探讨了物质摄入量，灰质体积和工作记忆任务性能之间的关联。在工作记忆任务中，接受OMT的患者比健康人犯了更多的错误，并且表现出更小的GMV和GMV。OMT前使用海洛因的持续时间与患者的工作记忆表现和GMV相关。无论是替代剂（美沙酮和丁丙诺啡），也不同时滥用非法物质在3个月前的实验是显着相关的GMV。结果表明，受损的工作记忆性能和结构缺陷的阿片类药物依赖患者的大脑中的海洛因使用的持续时间有关。这表明，早期纳入OMT或以戒断为导向的治疗，缩短海洛因滥用的时间可能会限制阿片类药物依赖者的GMV和认知能力的损害。
Opioid-dependent patients frequently show deficits in multiple cognitive domains that might impact on their everyday life performance and interfere with therapeutic efforts. To date, the neurobiological underpinnings of those deficits remain to be determined. We investigated working memory performance and gray matter volume (GMV) differences in 17 patients on opioid maintenance treatment (OMT) and 17 healthy individuals using magnetic resonance imaging and voxel-based morphometry. In addition, we explored associations between substance intake, gray matter volume, and working memory task performance. Patients on OMT committed more errors during the working memory task than healthy individuals and showed smaller insula and putamen GMV. The duration of heroin use prior to OMT was associated with working memory performance and insula GMV in patients. Neither the substitution agent (methadone and buprenorphine) nor concurrent abuse of illegal substances during the 3 months prior to the experiment was significantly associated with GMV. Results indicate that impaired working memory performance and structural deficits in the insula of opioid-dependent patients are related to the duration of heroin use. This suggests that early inclusion into OMT or abstinence-oriented therapies that shorten the period of heroin abuse may limit the impairments to GMV and cognitive performance of opioid-dependent individuals.