Oxygen-Generating Cyanobacteria Powered by Upconversion-Nanoparticles-Converted Near-Infrared Light for Ischemic Stroke Treatment
Oxygen-Generating Cyanobacteria Powered by Upconversion-Nanoparticles-Converted Near-Infrared Light for Ischemic Stroke Treatment
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由上转换纳米粒子转换的近红外光驱动的产氧蓝细菌用于治疗缺血性中风
DOI：
10.1021/acs.nanolett.1c00719
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发表时间：
2021
期刊：
影响因子：
10.8
通讯作者：
Wang Lin
中科院分区：
文献类型：
--
作者：
Wang Jian;Su Qiangfei;Lv Qiying;Cai Bo;Xiaohalati Xiakeerzhati;Wang Guobin;Wang Zheng;Wang Lin
Stroke is one of most common causes of death and disability. Most of neuroprotective agents fail to rescue neurons from cerebral ischemic insults, mainly because of targeting downstream cascading events, such as excitotoxicity, oxidative and nitrosative stress, and inflammation, rather than improving hypoxia that initially occurs. Here, we report a near-infrared light (NIR)-driven nanophotosynthesis biosystem capable of generating oxygen and absorbing carbon dioxide, thus rescuing neurons from ischemia toward treating stroke. Through cerebral delivery ofS. elongatusthat spontaneously photosynthesize and upconversion nanoparticles (UCNPs), NIR with excellent tissue penetrating capability is converted to visible light by UCNPs to activateS. elongatusgenerating oxygenin vivo, enhancing angiogenesis, reducing infarction, and facilitating repair of brain tissues, thus improving neuronal function recovery. The combination of cell-biological, biochemical, and animal-level behavioral data provides compelling evidence demonstrating that this oxygen-generating biosystem through jointly utilizing microorganism and nanotechnology represents a novel approach to stroke treatment.
