Regional brain uptake of 2-deoxy-D-glucose following training in a discriminated y-maze avoidance task.
Regional brain uptake of 2-deoxy-D-glucose following training in a discriminated y-maze avoidance task.
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在有区别的 y 迷宫回避任务训练后，区域大脑摄取 2-脱氧-D-葡萄糖。
DOI：
10.1037/h0077922
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Messing,RB
中科院分区：
文献类型：
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作者：
MartinezJr,JL;Petty,C;Messing,RB
在30只Swiss-Webster小鼠中测量了在辨别Y迷宫回避任务中训练后2-脱氧右旋-[-1-4C]葡萄糖（2-DG）的局部脑摄取。与30个不能逃脱电击的对照组相比，训练组海马中2-DG的摄取减少，纹状体中2-DG的摄取增加。实验组和对照组大鼠纹状体皮层的2-DG摄取无明显差异。其他对照研究表明，乙醚麻醉或2-DG给药途径（iv或ip）不影响2-DG脑摄取。结果表明，训练后局部脑区的代谢活动可能反映了这些结构在学习和记忆过程中的参与。（9参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Regional brain uptake of 2-deoxydextro-[–1–4C] glucose (2-DG) was measured in 30 Swiss-Webster mice following training in a discriminated Y-maze avoidance task. In comparison with 30 yoked-control Ss that could not escape the footshock, trained Ss had decreased uptake of 2-DG in the hippocampus and increased uptake in the striatum. There was no difference in 2-DG uptake between experimental and control Ss in the cortex overlying the striatum. Additional control studies showed that 2-DG uptake into the brain was not influenced by ether anesthetization or the route of 2-DG administration (iv or ip). Results indicate that the metabolic activity of regional brain areas following training may reflect the involvement of these structures in learning and memory processes.(9 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)