Molecular determinants of brown adipocyte formation and function
Molecular determinants of brown adipocyte formation and function
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DOI：
10.1101/gad.1681308
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发表时间：
2008-05-15
影响因子：
10.5
通讯作者：
Farmer, Stephen R.
中科院分区：
文献类型：
--
作者：
Farmer, Stephen R.
人类基本上含有两种类型的脂肪组织：棕色脂肪组织（BAT）和白色脂肪组织（WAT）。WAT的功能是储存脂肪，而BAT的功能是燃烧脂肪产生热量。对抗肥胖及其相关疾病的一个潜在策略是诱导WAT转化为BAT。在这个问题的基因与发展，Kajimura和他的同事（pp。1397-1409）已经鉴定了一种机制，通过该机制，PRDM 16（棕色脂肪细胞形成和功能的主要调节剂）可以同时诱导BAT基因表达，同时抑制WAT基因表达。这些研究表明，PRDM 16及其相关的协同调节因子PPAR γ共激活因子-1 α（PGC-1 α）和C末端结合蛋白1/2（CtBP 1/2）控制着从WAT到BAT的转换，是开发肥胖相关疗法的潜在靶点。
Humans contain essentially two types of adipose tissue: brown adipose tissue (BAT) and white adipose tissue (WAT). The function of WAT is to store fat while that of BAT is to burn fat for heat production. A potential strategy to combat obesity and its related disorders is to induce the conversion of WAT into BAT. In this issue of Genes & Development, Kajimura and colleagues (pp. 1397-1409) have identified a mechanism by which PRDM16, the principal regulator of brown adipocyte formation and function, can simultaneously induce BAT gene expression, while suppressing WAT gene expression. The studies suggest that PRDM16 and its associated coregulators PPAR gamma coactivator-1 alpha (PGC-1 alpha) and C-terminal-binding protein 1/2 (CtBP1/2), which control the switch from WAT to BAT, are potential targets for development of obesity-related therapeutics.