Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study
Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study
复制标题
恒河猴婴儿期晚期大脑发育和苯环己哌啶的影响：纵向 MRI 和 DTI 研究
DOI：
10.1016/j.neuroimage.2014.11.056
复制
发表时间：
2015-02-15
期刊：
影响因子：
5.7
通讯作者：
Wang, Jianhong
中科院分区：
文献类型：
--
作者：
Liu, Cirong;Tian, Xiaoguang;Wang, Jianhong
脑的早期发育是一个复杂而快速的过程，其紊乱可能导致脑功能障碍的发生。基于从出生后6至16个月获得的纵向成像数据，我们描述了一个系统的轨迹猴脑发育在婴儿后期，并证明苯环利定（PCP）对这一轨迹的影响。虽然猴子大脑的一般发育轨迹与人类大脑的发育轨迹接近，但猴子的发育速度更快，并且具有区域特异性。猴子的灰质体积在婴儿晚期开始减少，比人类的青春期早得多。此外，高级关联区域（额叶、顶叶和颞叶）的灰质体积的减少发生在主要功能区域（枕叶和小脑）之后。大部分脑区的白色物质体积均呈增加趋势，但枕叶的体积不明显，而枕叶的体积较为稳定。此外，基于扩散张量成像，我们发现分数各向异性增加和扩散率降低，这可能与白色物质束的髓鞘形成和轴突变化有关。同时，我们测试了14天的PCP处理对发育轨迹的影响。这种治疗往往会加速婴儿后期的大脑成熟，尽管没有统计学意义。这些发现为了解灵长类动物脑成熟和神经发育障碍提供了比较信息。(C)2014爱思唯尔公司All rights reserved.
Early brain development is a complex and rapid process, the disturbance of which may cause the onset of brain disorders. Based on longitudinal imaging data acquired from 6 to 16 months postnatal, we describe a systematic trajectory of monkey brain development during late infancy, and demonstrate the influence of phencyclidine (PCP) on this trajectory. Although the general developmental trajectory of the monkey brain was close to that of the human brain, the development in monkeys was faster and regionally specific. Gray matter volume began to decrease during late infancy in monkeys, much earlier than in humans in whom it occurs in adolescence. Additionally, the decrease of gray matter volume in higher-order association regions (the frontal, parietal and temporal lobes) occurred later than in regions for primary functions (the occipital lobe and cerebellum). White matter volume displayed an increasing trend in most brain regions, but not in the occipital lobe, which had a stable volume. In addition, based on diffusion tensor imaging, we found an increase in fractional anisotropy and a decrease in diffusivity, which may be associated with myelination and axonal changes in white matter tracts. Meanwhile, we tested the influence of 14-day PCP treatment on the developmental trajectories. Such treatment tended to accelerated brain maturation during late infancy, although not statistically significant. These findings provide comparative information for the understanding of primate brain maturation and neurodevelopmental disorders. (C) 2014 Elsevier Inc. All rights reserved.