THE 2ND NATION-WIDE SURVEY IN JAPAN OF VITAMIN-K DEFICIENCY IN INFANCY
THE 2ND NATION-WIDE SURVEY IN JAPAN OF VITAMIN-K DEFICIENCY IN INFANCY
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DOI：
10.1007/bf00441969
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发表时间：
1988-06-01
影响因子：
3.6
通讯作者：
SAWADA, K
中科院分区：
文献类型：
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作者：
HANAWA, Y;MAKI, M;SAWADA, K
从1981年1月至1985年6月，日本全国共报告了543例2周龄以上婴儿维生素K缺乏症。在这些病例中，427例没有明显的维生素K缺乏症的原因;这种情况被称为“婴儿期特发性维生素K缺乏症”。另有57例因维生素K缺乏伴明显肝胆病变、慢性腹泻、长期抗生素治疗等而出现出血发作，称为“婴儿继发性维生素K缺乏症”。第三组包括59例病例，属于所谓的“未遂”型，在大多数病例中，在大规模筛查时，Normotest发现了出血倾向，但没有任何明显的临床出血。在特发性组中，269例（63.0%）在1 - 2个月内发生出血事件，387例（90.0%）完全母乳喂养。本组353例（82.7%）观察到颅内出血。此外，在特发性组中观察到血清转氨酶和直接型胆红素水平轻微升高。不明原因的肝功能障碍可能在婴儿期维生素K缺乏症的发病中起一定作用。
Throughout Japan a total of 543 cases of vitamin K deficiency occurring in infants over 2 weeks of age were reported from January 1981 to June 1985. Of these cases, 427 showed no obvious reasons for vitamin K deficiency; this sort of case is known as "idiopathic vitamin K deficiency in infancy". Another 57 cases had bleeding episodes due to vitamin K deficiency associated with obvious hepatobiliary lesions, chronic diarrhoea, long-term antibiotic therapy, etc; this sort is called "secondary vitamin K deficiency in infancy". The third group, consisting of 59 cases, was made up of the socalled "near miss" type, in which a haemorrhagic tendency, without any obvious clinical haemorrhage, was discovered by Normotest, at the time of mass screening in most cases. In the idiopathic group, 269 cases (63.0%) developed bleeding episodes between the 1st and 2nd months of age, and 387 cases (90.0%) were entirely breast-fed. Intracranial haemorrhage was observed in 353 cases (82.7%) of this group. Moreover, slight elevation of serum transaminase and direct type bilirubin levels were observed in the idiopathic group. Liver dysfunction of unknown origin may play some role in the onset of vitamin K deficiency in infancy.