Molecular Imaging of Myocardial Inflammation With Positron Emission Tomography Post-Ischemia A Determinant of Subsequent Remodeling or Recovery
Molecular Imaging of Myocardial Inflammation With Positron Emission Tomography Post-Ischemia A Determinant of Subsequent Remodeling or Recovery
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DOI：
10.1016/j.jcmg.2018.05.026
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发表时间：
2018-09-01
影响因子：
14
通讯作者：
Bengel, Frank M.
中科院分区：
文献类型：
--
作者：
Thackeray, James T.;Bengel, Frank M.
心肌缺血后的炎症影响心室重构和修复，并已成为治疗靶点。常规诊断测量解决全身炎症，但不能量化局部组织变化。分子成像有助于无创评估白细胞浸润到受损心肌。F-18标记的氟脱氧葡萄糖（[F-18] FDG）的初步经验表明，梗死区域内的局部炎症细胞信号是随后心室功能障碍的独立预测因子。新的靶向放射性示踪剂可以提供额外的洞察特定白细胞群的富集。心肌梗死后炎症成像更广泛应用的挑战包括准确和可重复的定量、预后价值以及监测炎症对新治疗反应的能力。这篇综述描述了心肌缺血后的炎症作为分子成像靶点，并评估了已建立和新兴的放射性示踪剂的应用。此外，炎症成像提供预后信息，支持新药和治疗研究，并评估心脏疾病的生物反应的潜在作用进行了讨论。(C)2018年由美国心脏病学会基金会。
Inflammation after myocardial ischemia influences ventricular remodeling and repair and has emerged as a therapeutic target. Conventional diagnostic measurements address systemic inflammation but cannot quantify local tissue changes. Molecular imaging facilitates noninvasive assessment of leukocyte infiltration into damaged myocardium. Preliminary experience with F-18-labeled fluorodeoxyglucose ([F-18] FDG) demonstrates localized inflammatory cell signal within the infarct territory as an independent predictor of subsequent ventricular dysfunction. Novel targeted radiotracers may provide additional insight into the enrichment of specific leukocyte populations. Challenges to wider implementation of inflammation imaging after myocardial infarction include accurate and reproducible quantification, prognostic value, and capacity to monitor inflammation response to novel treatment. This review describes myocardial inflammation following ischemia as a molecular imaging target and evaluates established and emerging radiotracers for this application. Furthermore, the potential role of inflammation imaging to provide prognostic information, support novel drug and therapeutic research, and assess biological response to cardiac disease is discussed. (C) 2018 by the American College of Cardiology Foundation.