Iron-Based Tandem Catalysis: From Petroleum toward Pharmaceutical Laboratories for Organic Undergraduate Students─Product Identification by TLC and 1 H NMR
Iron-Based Tandem Catalysis: From Petroleum toward Pharmaceutical Laboratories for Organic Undergraduate Students─Product Identification by TLC and 1 H NMR
复制标题
铁基串联催化：从石油到有机本科生制药实验室——通过 TLC 和 1 H NMR 进行产品鉴定
DOI：
10.1021/acs.jchemed.2c00451
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发表时间：
2022
影响因子：
3
通讯作者：
Mlsna, Deb
中科院分区：
文献类型：
--
作者：
Smith, Lisa;Udayanga, D. M.;Qian, Xiaolin;Adams, Lauren;Sims, Sarah;Nettles, Charles;Xu, Xue;Cui, Xin;Mlsna, Deb
催化和催化循环广泛应用于研究和工业领域。在本科生实验室课程中增加催化实验是扩展学生学习的重要且必要的培训。在这里，密西西比州立大学二年级和高年级本科生的有机化学课程中开发并实施了一项展示铁基串联催化的实验。实验使用TLC和1H NMR来跟踪反应并鉴定实验过程中产生的核心药物结构。催化循环内包含的反应包括亚胺生成、亚氨基烯缩合和氮杂普林斯反应。催化循环方法可以减少反应时间、化学品和废物的产生。该实验在一所重点大学经过两个学期（110 名学生）的成功测试。达到了学习目标，以支持学生理解催化循环和反应机制。该实验室实验提供了使用 TLC 和 1 H NMR 来识别从石油中生产的药物化合物的核心结构的实践经验。
Catalysis and catalytic cycles are widely used in both research and industry. The addition of a catalysis experiment into the undergraduate laboratory curriculum is important and necessary training to expand student learning. Here, an experiment demonstrating iron-based tandem catalysis was developed and implemented in an organic chemistry course for second-year and upper-division undergraduate students at Mississippi State University. The experiment uses TLC and1H NMR to track the reaction and identify the core pharmaceutical structure produced during the experiment. Reactions contained inside the catalytic cycles include iminium generation, imino-ene condensation, and aza-Prins reaction. The catalytic cycle approach allows for a decrease in time for reaction, chemicals, and waste produced. This experiment was successfully tested over two semesters (110 students) at a major university. Learning objectives were met to support student understanding of catalytic cycles and reaction mechanisms. This laboratory experiment provided hands-on experience using TLC and1H NMR to identify a core structure of pharmaceutical compounds produced from petroleum.