Abnormal speech sound representation in persistent developmental stuttering
Abnormal speech sound representation in persistent developmental stuttering
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DOI：
10.1212/01.wnl.0000180969.03719.81
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发表时间：
2005-10-25
期刊：
影响因子：
9.9
通讯作者：
Idiazábal, MA
中科院分区：
文献类型：
--
作者：
Corbera, S;Corral, MJ;Idiazábal, MA
目的：探讨成人持续性发展性口吃（PDS）是否存在听觉感知障碍。研究方法：作者比较了PDS受试者样本与配对流利对照受试者样本中记录的纯音（频率和持续时间）和语音对比引起的失配负波（MMN）事件相关脑电位。结果如下：受试者与发展性口吃有正常的MMN简单的音调对比，但一个显着的颞上左侧增强的电生理反应语音对比。此外，增强的MMN与受试者自评的言语不流利呈正相关。结论：持续性发展性口吃的个体具有异常的永久性语音痕迹，其异常的语音表征可能是其言语障碍的基础。听觉皮层的异常言语神经痕迹和言语不流利之间的联系支持言语感知机制与言语产生的相关性。
Objectives: To determine whether adults with persistent developmental stuttering (PDS) have auditory perceptual deficits. Methods: The authors compared the mismatch negativity (MMN) event-related brain potential elicited to simple tone ( frequency and duration) and phonetic contrasts in a sample of PDS subjects with that recorded in a sample of paired fluent control subjects. Results: Subjects with developmental stuttering had normal MMN to simple tone contrasts but a significant supratemporal left-lateralized enhancement of this electrophysiologic response to phonetic contrasts. In addition, the enhanced MMN correlated positively with speech disfluency as self-rated by the subjects. Conclusions: Individuals with persistent developmental stuttering have abnormal permanent traces for speech sounds, and their abnormal speech sound representation may underlie their speech disorder. The link between abnormal speech neural traces of the auditory cortex and speech disfluency supports the relevance of speech perception mechanisms to speech production.