IFN-λ:: Novel antiviral cytokines
IFN-λ:: Novel antiviral cytokines
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DOI：
10.1089/jir.2006.26.373
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发表时间：
2006-06-01
影响因子：
2.3
通讯作者：
Paludan, Soren R.
中科院分区：
文献类型：
--
作者：
Ank, Nina;West, Hans;Paludan, Soren R.
对抗病毒感染的第一道防线是由干扰素S介导的，受感染的宿主迅速产生干扰素。已知I型干扰素(干扰素-α/β)通过直接抑制细胞内的病毒复制和间接通过刺激先天和获得性免疫反应来对抗病毒。最近，一类新的细胞因子被发现，命名为干扰素-lambda(也称为III型干扰素或白介素28/29[IL-28/29])，基于干扰素样抗病毒活性和典型的干扰素诱导基因的诱导。在这里，我们回顾了关于干扰素-lambda的文献，并讨论了目前对干扰素-lambda的功能和作用机制的认识。
The first line of defense against viral infections is mediated by interferons (IFN)s, which are produced rapidly by the infected host. Type I IFNs (IFN-alpha/beta) are known to combat viruses both directly by inhibiting viral replication in the cells and indirectly by stimulating the innate and adaptive immune responses. Recently, a novel class of cytokines was discovered and named IFN-lambda (alternatively type III IFN or interleukin-28/29 [IL-28/ 29]), based on IFN-like antiviral activity and induction of typical IFN- inducible genes. Here, we review the literature on IFN-lambda and discuss the current knowledge of the functions and mechanisms of action of IFN-lambda.