Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus
Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus
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DOI：
10.1111/j.1365-2249.2009.03880.x
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发表时间：
2009-04-01
影响因子：
4.6
通讯作者：
Howe, H. S.
中科院分区：
文献类型：
--
作者：
Kong, K. O.;Tan, A. W.;Howe, H. S.
目的探讨干扰素诱导蛋白-10（IP-10）在系统性红斑狼疮（SLE）患者血清中的水平及其与疾病活动性和器官表现的相关性。在464例SLE患者和50例健康供体中评估血清IP-10水平。通过修订的SLE活动性测量评估疾病活动性，并记录伴随的活动器官表现、抗dsDNA抗体滴度、补体水平和红细胞沉降率。通过体外培养用丝裂原或脂多糖刺激，测定SLE患者和对照者外周血单个核细胞（PBMC）IP-10的合成。在SLE患者中观察到血清IP-10水平升高，在存在活动性血液学和皮肤粘膜表现的情况下，血清IP-10水平显著更高。SLE PBMC在体外表现出增强的自发IP-10产生。连续IP-10水平与SLE活动的纵向变化相关，即使在抗dsDNA抗体和补体水平保持不变的低水平下。这些数据表明，IP-10水平增加，SLE和血清IP-10可能代表一个更敏感的标志物监测疾病的活动比标准的血清学试验。
Our objective was to investigate the serum levels of interferon-inducible protein-10 (IP-10) in systemic lupus erythematosus (SLE) and their correlation with disease activity and organ manifestations. Serum IP-10 levels were assessed in 464 SLE patients and 50 healthy donors. Disease activity was assessed by the revised SLE Activity Measure, and the concomitant active organ manifestations, anti-ds DNA antibody titres, complement levels and erythrocyte sedimentation rates recorded. Peripheral blood mononuclear cell (PBMC) synthesis of IP-10 in SLE patients and controls was determined by in vitro cultures stimulated with mitogen or lipopolysaccharide. Elevated serum IP-10 levels were observed in SLE patients, which were significantly higher in the presence of active haematological and mucocutaneous manifestations. SLE PBMCs exhibited enhanced spontaneous IP-10 production in vitro. Serial IP-10 levels correlated with longitudinal change in SLE activity, even at low levels where anti-dsDNA antibody and complement levels remain unchanged. These data demonstrate that IP-10 levels are increased in SLE and serum IP-10 may represent a more sensitive marker for monitoring disease activity than standard serological tests.