A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids.
A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids.
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DOI：
10.1016/j.bbrc.2009.07.130
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发表时间：
2009-10-09
影响因子：
3.1
通讯作者：
Salati, Lisa M.
中科院分区：
文献类型：
--
作者：
Kohan, Alison B.;Talukdar, Indrani;Walsh, Callee M.;Salati, Lisa M.
Both polyunsaturated fatty acids and AMPK promote energy partitioning away from energy consuming processes, such as fatty acid synthesis, towards energy generating processes, such as β-oxidation. In this report, we demonstrate that arachidonic acid activates AMPK in primary rat hepatocytes, and that this effect is p38 MAPK-dependent. Activation of AMPK mimics the inhibition by arachidonic acid of the insulin-mediated induction of G6PD. Similar to intracellular signaling by arachidonic acid, AMPK decreases insulin signal transduction, increasing Ser307 phosphorylation of IRS-1 and a subsequent decrease in AKT phosphorylation. Overexpression of dominant-negative AMPK abolishes the effect of arachidonic acid on G6PD expression. These data suggest a role for AMPK in the inhibition of G6PD by polyunsaturated fatty acids.
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影响因子：
3.5
作者：
CARLING, D;ZAMMIT, VA;HARDIE, DG
通讯作者：
HARDIE, DG
DOI：
10.1111/j.1432-1033.1990.tb15293.x
发表时间：
1990-01-12
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
DAVIES, SP;SIM, ATR;HARDIE, DG
通讯作者：
HARDIE, DG
影响因子：
3.7
作者：
SEGLEN, PO
通讯作者：
SEGLEN, PO
影响因子：
4.8
作者：
Talukdar, I;Szeszel-Fedorowicz, W;Salati, LM
通讯作者：
Salati, LM
影响因子：
4.8
作者：
Foretz, M;Carling, D;Foufelle, F
通讯作者：
Foufelle, F