High-level language difficulties in Parkinson's disease
High-level language difficulties in Parkinson's disease
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DOI：
10.1080/0269920021000055540
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发表时间：
2003-01-01
影响因子：
1.2
通讯作者：
Johnels, B
中科院分区：
文献类型：
--
作者：
Berg, E;Björnram, C;Johnels, B
26名患有特发性帕金森病（PD）和正常认知状态（通过简易精神状态检查测量）的受试者进行了检查，选择了一系列测试，以揭示微妙和/或高级语言障碍。成套测试包括“长句子重复”、“再创造句子”、"推理“、”逻辑-语法关系理解“、”歧义句理解“和”隐喻理解“、”词语定义“、”词语流畅性“、”命名“、”句子分析“和”形态补全“。PD受试者和26名年龄、性别和教育水平相匹配的对照受试者进行了比较。PD受试者和对照受试者之间的表现显着差异，发现在推理和分析句子的能力（国家的正确数量的单词在一个读句子）。另外四个不同程度的认知功能障碍的主题也进行了调查，发现有特殊的问题，在作出推断，重建句子和理解隐喻和歧义。结果表明，处理隐含的信息可能是一个特定的问题，在这一组和推理的任务可能是一个特别敏感的测试高层次的语言功能障碍。
Twenty-six subjects with idiopathic Parkinson's disease (PD) and normal cognitive status (as measured by the Mini-Mental State Examination) were examined with a battery of tests selected to reveal subtle and/or high-level language impairments. The test battery included 'repetition of long sentences', 'recreating sentences', 'making inferences', 'comprehension of logico-grammatical sentences', 'comprehension of ambiguous sentences' and 'comprehension of metaphors', 'word definitions', 'word fluency', 'naming', 'sentence analysis' and 'morphological completion'. Comparisons were made between the PD subjects and 26 control subjects matched for age, gender and level of education. Significant differences in performance between the PD subjects and the control subjects were found in the ability to make inferences and to analyse sentences (state the correct number of words in a read sentence). An additional four subjects with different degrees of cognitive dysfunction were also investigated and were found to have particular problems in making inferences, recreating sentences and comprehending metaphors and ambiguities. The results suggest that processing implied information might be a specific problem in this group and that the task of making inferences could be a particularly sensitive test of high-level language dysfunction.