Approaches to assessing combination effects of oestrogenic environmental pollutants
Approaches to assessing combination effects of oestrogenic environmental pollutants
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DOI：
10.1016/s0048-9697(99)00228-4
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发表时间：
1999-08-15
影响因子：
9.8
通讯作者：
Altenburger, R
中科院分区：
文献类型：
--
作者：
Kortenkamp, A;Altenburger, R
对环境化学物质与雌激素活性可能产生的联合效应的关注促使人们寻找这些物质之间的协同作用。然而，许多已发表的工作没有考虑到毒理学和药理学中发展起来的分析联合效应的概念和方法。在本通讯中，我们提请注意与合理分析雌激素化合物混合物的作用有关的概念框架。模型计算表明，可以想象，弱雌激素化合物可能能够共同作用，产生显著的效果，即使它们存在的浓度低于其单独的影响阈值。我们的研究结果表明，可能没有必要调用协同作用来解释这些试剂在体外测定系统中产生作用所需的高浓度与在环境中的低浓度之间的差异。(C) 1999 Elsevier Science B.V.版权所有
Concerns about possible combination effects of environmental chemicals with estrogenic activity have motivated the search for synergisms between such agents. However, much published work has taken no account of the concepts and methods for analysing combination effects, which were developed in toxicology and pharmacology. In the present communication, we draw attention to conceptual frameworks relevant for a sound analysis of the effects of mixtures of oestrogenic compounds. A model calculation is presented demonstrating that it is conceivable that weakly oestrogenic compounds may be able to act together to produce significant effects, even when they are present at concentrations below their individual effect thresholds. Our results suggest that it may not be necessary to invoke synergisms in order to explain the discrepancy between the high concentrations of these agents required to produce effects in in vitro assay systems and their low concentrations in the environment. (C) 1999 Elsevier Science B.V. All rights reserved.