Speech networks at rest and in action: interactions between functional brain networks controlling speech production.
Speech networks at rest and in action: interactions between functional brain networks controlling speech production.
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DOI：
10.1152/jn.00964.2014
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发表时间：
2015-04
影响因子：
2.5
通讯作者：
K. Simonyan;Stefan Fuertinger
中科院分区：
文献类型：
--
作者：
K. Simonyan;Stefan Fuertinger
言语产生是人类最复杂的行为之一。虽然人们已经对说话时的大脑激活进行了很好的研究，但我们对大脑区域和神经网络之间的相互作用的理解仍然很少。我们将基于种子的区域间相关性分析与健康受试者静息状态和句子生成期间功能性MRI数据的图论分析相结合，以研究源自控制语音的关键脑区的功能网络的接口和拓扑结构，即，喉/口面运动皮层、额下回和上级颞回、辅助运动区、扣带皮层、壳核和丘脑。在休息和说话期间，这些网络之间的相互作用是双边分布的，并集中在感觉运动脑区。然而，语音生产优先招募顶叶下小叶（IPL）和小脑到大规模的网络，这表明这些地区的重要性，促进从休息状态到说话的过渡。此外，小脑（小叶VI）是最突出的区域显示功能的影响，语音网络的整合和分离。虽然网络是双边分布的，区域间的连接在说话时更强的左半球与右半球，这可能强调了一个更均匀的重叠在左半球的检查网络。其中，喉运动皮层（LMC）建立了一个核心网络，与所有其他语音相关的网络完全重叠，决定了网络相互作用的程度。我们的数据显示了控制语音产生的大规模大脑网络的复杂相互作用，并指出了LMC，IPL和小脑在语音产生网络形成中的关键作用。
Speech production is one of the most complex human behaviors. Although brain activation during speaking has been well investigated, our understanding of interactions between the brain regions and neural networks remains scarce. We combined seed-based interregional correlation analysis with graph theoretical analysis of functional MRI data during the resting state and sentence production in healthy subjects to investigate the interface and topology of functional networks originating from the key brain regions controlling speech, i.e., the laryngeal/orofacial motor cortex, inferior frontal and superior temporal gyri, supplementary motor area, cingulate cortex, putamen, and thalamus. During both resting and speaking, the interactions between these networks were bilaterally distributed and centered on the sensorimotor brain regions. However, speech production preferentially recruited the inferior parietal lobule (IPL) and cerebellum into the large-scale network, suggesting the importance of these regions in facilitation of the transition from the resting state to speaking. Furthermore, the cerebellum (lobule VI) was the most prominent region showing functional influences on speech-network integration and segregation. Although networks were bilaterally distributed, interregional connectivity during speaking was stronger in the left vs. right hemisphere, which may have underlined a more homogeneous overlap between the examined networks in the left hemisphere. Among these, the laryngeal motor cortex (LMC) established a core network that fully overlapped with all other speech-related networks, determining the extent of network interactions. Our data demonstrate complex interactions of large-scale brain networks controlling speech production and point to the critical role of the LMC, IPL, and cerebellum in the formation of speech production network.