Glycyrrhizin, a Potential Drug for Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1
Glycyrrhizin, a Potential Drug for Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1
复制标题
甘草甜素，一种通过抑制高迁移率群来治疗自身免疫性脑脊髓炎的潜在药物 Box 1
DOI：
10.1089/dna.2018.4444
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发表时间：
2018-10-16
影响因子：
3.1
通讯作者：
Zheng, Fang
中科院分区：
文献类型：
--
作者：
Li, Jun;Shi, Junyu;Zheng, Fang
自身免疫性脑脊髓炎是一种由免疫介导的无菌性炎症反应和中枢神经系统脱髓鞘引起的慢性自身免疫性疾病。高迁移率族蛋白1（HMGB1）是一种普遍存在的核蛋白，它可以从受损细胞中释放出来，并在自身免疫性脑脊髓炎中诱导促炎反应。甘草皂苷（GL）是甘草的主要成分，可抑制HMGB1的促炎生物活性。在这篇文章中，我们带来了一些见解GL对中枢神经系统炎症性疾病的影响，并讨论了GL在自身免疫性脑脊髓炎的治疗潜力，在未来。
Autoimmune encephalomyelitis is a chronic autoimmune disease caused by immune-mediated sterile inflammatory response and demyelination in the central nervous system (CNS). High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein, which can be released from damaged cells and induce proinflammatory responses in autoimmune encephalomyelitis. Glycyrrhizin (GL), a major constituent of licorice root, can inhibit the proinflammatory bioactivities of HMGB1. In this article, we bring some insight into the effects of GL on CNS inflammatory diseases and discuss the therapeutic potential of GL in autoimmune encephalomyelitis in the future.