IN VIVO NEAR-INFRARED SPECTROSCOPY AND MAGNETIC RESONANCE IMAGING MONITORING OF TUMOR RESPONSE TO COMBRETASTATIN A-4-PHOSPHATE CORRELATED WITH THERAPEUTIC OUTCOME
IN VIVO NEAR-INFRARED SPECTROSCOPY AND MAGNETIC RESONANCE IMAGING MONITORING OF TUMOR RESPONSE TO COMBRETASTATIN A-4-PHOSPHATE CORRELATED WITH THERAPEUTIC OUTCOME
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DOI：
10.1016/j.ijrobp.2010.12.028
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发表时间：
2011-06-01
影响因子：
7
通讯作者：
Mason, Ralph P.
中科院分区：
文献类型：
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作者：
Zhao, Dawen;Chang, Cheng-Hui;Mason, Ralph P.
目的：根据肿瘤的氧合状态，开发一种由考布他汀A-4-磷酸（CA 4P）和放射组成的联合治疗。方法和材料：应用近红外光谱（NIRS）和弥散加权（DW）磁共振成像（MRI）无创监测CA 4 P诱导的肿瘤血氧和坏死的变化（30 mg/kg）对大鼠乳腺癌13762 NF的作用，并将证据用于优化CA 4P和放射治疗的组合。（单次剂量为5戈伊）。NIRS显示CA 4P治疗后前2小时内肿瘤血管氧合血红蛋白和总血红蛋白浓度降低，表明肿瘤血氧和灌注水平显著降低（P < 0.001）。24小时后，根据NIRS和pimonidazole染色结果分别观察到对吸氧的响应，肿瘤血管和组织氧合显著恢复（p
Purpose: To develop a combination treatment consisting of combretastatin A-4-phosphate (CA4P) with radiation based on tumor oxygenation status.Methods and Materials: In vivo near-infrared spectroscopy (NIRS) and diffusion-weighted (DW) magnetic resonance imaging (MRI) were applied to noninvasively monitor changes in tumor blood oxygenation and necrosis induced by CA4P (30 mg/kg) in rat mammary 13762NF adenocarcinoma, and the evidence was used to optimize combinations of CA4P and radiation treatment (a single dose of 5 Gy).Results: NIRS showed decreasing concentrations of tumor vascular oxyhemoglobin and total hemoglobin during the first 2 h after CA4P treatment, indicating significant reductions in tumor blood oxygenation and perfusion levels (p < 0.001). Twenty-four hours later, in response to oxygen inhalation, significant recovery was observed in tumor vascular and tissue oxygenation according to NIRS and pimonidazole staining results, respectively (p