Antioxidant defense in Plasmodium falciparum -: data mining of the transcriptome -: art. no. 23
Antioxidant defense in Plasmodium falciparum -: data mining of the transcriptome -: art. no. 23
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DOI：
10.1186/1475-2875-3-23
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发表时间：
2004-07-01
期刊：
影响因子：
3
通讯作者：
Ginsburg, H
中科院分区：
文献类型：
--
作者：
Bozdech, Z;Ginsburg, H
红细胞内疟疾寄生虫处于来自内源性和外源性过程的恒定氧化应激下。寄生虫被赋予了一个完整的酶和蛋白质网络，保护它免受这些威胁，但也使用氧化还原活性来调节酶的活性。在本分析中，在红细胞内循环的时间框架内观察编码抗氧化防御元件的基因的转录。时间依赖性转录数据取自人类疟疾寄生虫恶性疟原虫的转录组。尽管对于几个过程，许多参与基因的转录是协调的，但在本例中存在一些突出的偏差，其中利用谷胱甘肽或硫氧还蛋白的基因产物在编码控制这些底物水平的元件的基因被转录之前被转录。这些见解可能暗示着需要进一步研究的新的非经典途径。
The intraerythrocytic malaria parasite is under constant oxidative stress originating both from endogenous and exogenous processes. The parasite is endowed with a complete network of enzymes and proteins that protect it from those threats, but also uses redox activities to regulate enzyme activities. In the present analysis, the transcription of the genes coding for the antioxidant defense elements are viewed in the time-frame of the intraerythrocytic cycle. Time-dependent transcription data were taken from the transcriptome of the human malaria parasite Plasmodium falciparum. Whereas for several processes the transcription of the many participating genes is coordinated, in the present case there are some outstanding deviations where gene products that utilize glutathione or thioredoxin are transcribed before the genes coding for elements that control the levels of those substrates are transcribed. Such insights may hint to novel, non-classical pathways that necessitate further investigations.