Older but Not Wiser: the Age-Driven Changes in Neutrophil Responses during Pulmonary Infections.
Older but Not Wiser: the Age-Driven Changes in Neutrophil Responses during Pulmonary Infections.
复制标题
年长但不聪明：肺部感染期间中性粒细胞反应的年龄驱动变化。
DOI：
10.1128/iai.00653-20
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发表时间：
2021
影响因子：
3.1
通讯作者：
BouGhanem,ElsaN
中科院分区：
文献类型：
--
作者：
Simmons,ShaunnaR;Bhalla,Manmeet;Herring,SydneyE;Tchalla,EssiYI;BouGhanem,ElsaN
老年人患危及生命的肺部感染的风险增加。中性粒细胞是病原体诱导的肺炎病程的关键决定因素。最佳的宿主防御平衡了最初强大的肺中性粒细胞反应，以控制病原体数量，最终解决炎症，以防止肺损伤。最近的证据表明，中性粒细胞的表型和功能异质性影响宿主对肺部病原体的抵抗力。除了它们在先天免疫中的明显作用外，中性粒细胞还在感染期间协调随后的适应性免疫应答。因此，肺部感染的结果可以由中性粒细胞塑造。本文综述了年龄驱动的中性粒细胞反应损伤以及这些细胞对老年人对肺炎易感性的贡献。我们描述了衰老是如何伴随着中性粒细胞的募集，解决和功能的变化。我们讨论如何系统和局部的变化改变中性粒细胞表型在老年主机。我们强调的差距差距的知识是否这些变化在中性粒细胞也有助于适应性免疫力下降，随着年龄的增长。我们进一步详细介绍了驱动老年人中性粒细胞反应失调的因素，以及可能靶向重新平衡中性粒细胞活性和增强宿主对肺部感染抵抗力的途径。
Elderly individuals are at increased risk of life-threatening pulmonary infections. Neutrophils are a key determinant of the disease course of pathogen-induced pneumonia. Optimal host defense balances initial robust pulmonary neutrophil responses to control pathogen numbers, ultimately followed by the resolution of inflammation to prevent pulmonary damage. Recent evidence suggests that phenotypic and functional heterogeneity in neutrophils impacts host resistance to pulmonary pathogens. Apart from their apparent role in innate immunity, neutrophils also orchestrate subsequent adaptive immune responses during infection. Thus, the outcome of pulmonary infections can be shaped by neutrophils. This review summarizes the age-driven impairment of neutrophil responses and the contribution of these cells to the susceptibility of the elderly to pneumonia. We describe how aging is accompanied by changes in neutrophil recruitment, resolution, and function. We discuss how systemic and local changes alter the neutrophil phenotype in aged hosts. We highlight the gap in knowledge of whether these changes in neutrophils also contribute to the decline in adaptive immunity seen with age. We further detail the factors that drive dysregulated neutrophil responses in the elderly and the pathways that may be targeted to rebalance neutrophil activity and boost host resistance to pulmonary infections.